OTUD3
OTUD3,即OTU結(jié)構(gòu)域含蛋白3,別名OTUD7B、JAMM-2、JAMM2等。它是一種由OTUD3基因編碼的蛋白質(zhì),屬于OTU蛋白酶家族成員,在細(xì)胞內(nèi)具有去泛素化酶活性。OTUD3的作用機(jī)制涉及其OTU結(jié)構(gòu)域,該結(jié)構(gòu)域賦予了它特異性去除蛋白質(zhì)上泛素化修飾的能力,參與調(diào)控蛋白質(zhì)的穩(wěn)定性和信號(hào)傳導(dǎo)過(guò)程。OTUD3的功能異常與多種疾病有關(guān),包括某些類型的癌癥、神經(jīng)退行性疾病等。研究表明,OTUD3通過(guò)去泛素化修飾影響p53蛋白的穩(wěn)定性,進(jìn)而影響細(xì)胞對(duì)DNA損傷的響應(yīng)。此外,OTUD3還在免疫細(xì)胞中發(fā)揮作用,調(diào)節(jié)炎癥反應(yīng)和細(xì)胞因子的產(chǎn)生。因此,OTUD3是細(xì)胞生物學(xué)和疾病研究中的一個(gè)重要分子靶點(diǎn)。
熱銷產(chǎn)品
OTUD3 Antibody (CSB-PA719399LA01HU)
驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: U251 whole cell lysate, U87 whole cell lysate
All lanes: OTUD3 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 46 kDa
Observed band size: 46 kDa

Immunofluorescence staining of U251 cells with CSB-PA719399LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
OTUD3 Antibodies
OTUD3 for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA719399LA01HU | OTUD3 Antibody | Human | ELISA, WB, IF |
CSB-PA719399LB01HU | OTUD3 Antibody, HRP conjugated | Human | ELISA |
CSB-PA719399LC01HU | OTUD3 Antibody, FITC conjugated | Human | |
CSB-PA719399LD01HU | OTUD3 Antibody, Biotin conjugated | Human | ELISA |
OTUD3 Proteins
OTUD3 Proteins for Homo sapiens (Human)
產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
---|---|---|
CSB-YP719399HU CSB-EP719399HU CSB-BP719399HU CSB-MP719399HU CSB-EP719399HU-B |
Recombinant Human OTU domain-containing protein 3 (OTUD3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |