P2RX3
P2RX3，即嘌呤能受體P2X配體門控離子通道3型蛋白，常被稱為P2X3受體，別名P2X3。P2RX3屬于ATP門控的非選擇性陽離子通道家族，主要分布于感覺神經(jīng)元末梢，通過與胞外ATP結(jié)合觸發(fā)鈉、鈣離子內(nèi)流，參與痛覺信號(hào)傳導(dǎo)及內(nèi)臟器官的神經(jīng)反射調(diào)控。研究發(fā)現(xiàn)，其過度激活與慢性咳嗽、膀胱過度活動(dòng)癥及糖尿病神經(jīng)病變密切相關(guān)，在神經(jīng)源性炎癥和內(nèi)臟超敏反應(yīng)中起關(guān)鍵作用。近年來針對(duì)P2X3受體的藥物開發(fā)取得突破，如首個(gè)高選擇性拮抗劑Gefapixant（AF-219）已完成Ⅲ期臨床試驗(yàn)，證實(shí)能顯著改善難治性慢性咳嗽患者癥狀，但存在味覺障礙副作用。另有Eliapixant（BAY-1817080）等二代藥物通過結(jié)構(gòu)優(yōu)化降低不良反應(yīng)，目前處于Ⅱ期研究階段。該靶點(diǎn)同時(shí)被探索用于治療間質(zhì)性膀胱炎和神經(jīng)病理性疼痛，其雙重拮抗劑（同時(shí)阻斷P2X2/3異源三聚體）在腸易激綜合征等疾病中展現(xiàn)出潛在治療價(jià)值。
熱銷產(chǎn)品
P2RX3 Antibody (CSB-PA017321ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: P2RX3 antibody at 3.91 μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 44 kDa
Observed band size: 44 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017321ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA017321ESR1HU at dilution of 1:100
P2RX3 Antibodies
P2RX3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA005140 | P2RX3 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA056352 | P2RX3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA017321ESR1HU | P2RX3 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA017321ESR2HU | P2RX3 Antibody | Human | ELISA, IHC |
P2RX3 Proteins
P2RX3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017321RA CSB-EP017321RA CSB-BP017321RA CSB-MP017321RA CSB-EP017321RA-B |
Recombinant Rat P2X purinoceptor 3 (P2rx3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
P2RX3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017321HU CSB-EP017321HU CSB-BP017321HU CSB-MP017321HU CSB-EP017321HU-B |
Recombinant Human P2X purinoceptor 3 (P2RX3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
P2RX3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP663676MO CSB-EP663676MO CSB-BP663676MO CSB-MP663676MO CSB-EP663676MO-B |
Recombinant Mouse P2X purinoceptor 3 (P2rx3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
