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PADI2

PADI2,即肽基精氨酸脫亞胺酶2,別名PAD2、PDI2、PAD-H19。它是一種由人類基因編碼的鈣依賴性酶,主要在多種組織中表達(dá),尤其在結(jié)腸、大腦和其他組織中表達(dá)量較高。PADI2的作用機(jī)制是通過催化蛋白質(zhì)的翻譯后脫亞胺化,將精氨酸殘基轉(zhuǎn)化為瓜氨酸,這一過程在鈣離子存在下進(jìn)行。PADI2在神經(jīng)退行性疾?。ㄈ绨柎暮D『投喟l(fā)性硬化癥)的發(fā)病和進(jìn)展中發(fā)揮作用,并且與青光眼的發(fā)病機(jī)制有關(guān)。PADI2還與多種腫瘤的遺傳易感性相關(guān),包括乳腺癌,是癌癥生物標(biāo)志物和潛在的治療靶點。

熱銷產(chǎn)品

Recombinant Human Protein-arginine deiminase type-2 (PADI2) (CSB-MP896493HU)

驗證數(shù)據(jù)

CSB-MP896493HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PADI2 Antibody (CSB-PA896493YA01HU)

驗證數(shù)據(jù)

CSB-PA896493YA01HU

Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: PADI2 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 76, 50 kDa
Observed band size: 76, 50 kDa

CSB-PA896493YA01HU

IHC image of CSB-PA896493YA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA896493YA01HU

Immunofluorescence staining of Hela cells with CSB-PA896493YA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PADI2 Antibodies

PADI2 for Homo sapiens (Human)

PADI2 Proteins

PADI2 Proteins for Homo sapiens (Human)