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PAK4

PAK4蛋白,全稱為p21蛋白(Cdc42/Rac)-激活的激酶4,也被稱為KIAA1142。它是一種絲氨酸/蘇氨酸激酶,在多種信號(hào)通路中發(fā)揮作用,影響細(xì)胞骨架調(diào)節(jié)、細(xì)胞遷移、生長(zhǎng)、增殖和細(xì)胞存活。PAK4蛋白在細(xì)胞形態(tài)、細(xì)胞骨架組織和細(xì)胞增殖遷移中起關(guān)鍵作用,并且可以作為抗凋亡蛋白。PAK4蛋白與多種疾病相關(guān),如腫瘤,其過(guò)表達(dá)在胰腺癌、胃癌和卵巢癌等多種腫瘤中較為常見(jiàn)。在藥物研發(fā)方面,針對(duì)PAK4蛋白的抗體和抑制劑正在研究,以用于治療相關(guān)疾病。

熱銷產(chǎn)品

Recombinant Human Serine/threonine-protein kinase PAK 4 (PAK4) (CSB-EP017408HU)

驗(yàn)證數(shù)據(jù)

CSB-EP017408HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PAK4 Antibody (CSB-PA05437A0Rb)

驗(yàn)證數(shù)據(jù)

CSB-PA05437A0Rb

Western Blot
Positive WB detected in: Rat lung tissue
All lanes: PAK4 antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 65, 48, 49, 55 kDa
Observed band size: 65 kDa

CSB-PA05437A0Rb

IHC image of CSB-PA05437A0Rb diluted at 1:800 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA05437A0Rb

IHC image of CSB-PA05437A0Rb diluted at 1:800 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA05437A0Rb

Immunofluorescence staining of Hela cells with CSB-PA05437A0Rb at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PAK4 Antibodies

PAK4 for Homo sapiens (Human)

PAK4 Proteins

PAK4 Proteins for Homo sapiens (Human)

PAK4 Proteins for Mus musculus (Mouse)