PARP2
PARP2，即聚（ADP-核糖）聚合酶2。別名ARTD2、ADPRT2、PARP-2、ADPRTL2、ADPRTL3、pADPRT-2。它在人體中廣泛表達(dá)，尤其在大腦和睪丸中的表達(dá)量較高。PARP2能夠催化聚（ADP-核糖）化反應(yīng)，這一過程對于DNA損傷修復(fù)至關(guān)重要。PARP2與PARP1功能類似，但在底物選擇上存在差異。PARP2參與DNA損傷響應(yīng)，尤其是在單鏈DNA斷裂的修復(fù)中發(fā)揮作用。它通過聚（ADP-核糖）化修飾多種核蛋白，包括組蛋白、RNA聚合酶、DNA聚合酶和DNA連接酶等，從而促進(jìn)DNA損傷修復(fù)過程。PARP2的活性也與細(xì)胞凋亡相關(guān)，其被Caspase剪切后會失去酶活力，這一剪切被認(rèn)為是細(xì)胞凋亡的一個(gè)重要指標(biāo)。PARP2的功能異常與多種疾病相關(guān)，包括范可尼貧血、輸卵管癌、遺傳性乳腺癌-卵巢癌綜合征等。
熱銷產(chǎn)品
Recombinant Human Poly [ADP-ribose] polymerase 2 (PARP2) (CSB-BP866224HUg6)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PARP2 Antibody (CSB-PA866224LA01HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: PC-3 whole cell lysate, HepG2 whole cell lysate
All lanes: PARP2 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 67, 65 kDa
Observed band size: 67 kDa
PARP2 Antibodies
PARP2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017466GA01HU | PARP2 Antibody | Human | ELISA,WB |
| CSB-PA152331 | PARP2 Antibody | Human | ELISA,WB |
| CSB-PA006369 | PARP2 Antibody | Human,Mouse | WB, ELISA |
| CSB-PA866224LA01HU | PARP2 Antibody | Human | ELISA, WB |
| CSB-PA866224LB01HU | PARP2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA866224LC01HU | PARP2 Antibody, FITC conjugated | Human | |
| CSB-PA866224LD01HU | PARP2 Antibody, Biotin conjugated | Human | ELISA |
PARP2 Proteins
PARP2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017466MO CSB-EP017466MO CSB-BP017466MO CSB-MP017466MO CSB-EP017466MO-B |
Recombinant Mouse Poly [ADP-ribose] polymerase 2 (Parp2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP2 Proteins for Zea mays (Maize)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP017466ZAX CSB-EP017466ZAX CSB-BP017466ZAX CSB-MP017466ZAX CSB-EP017466ZAX-B |
Recombinant Zea mays Poly [ADP-ribose] polymerase 2 (PARP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP2 Proteins for Arabidopsis thaliana (Mouse-ear cress)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP606137DOA CSB-EP606137DOA CSB-BP606137DOA CSB-MP606137DOA CSB-EP606137DOA-B |
Recombinant Arabidopsis thaliana Poly [ADP-ribose] polymerase 2 (PARP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PARP2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP866224HU CSB-MP866224HU CSB-EP866224HU-B |
Recombinant Human Poly [ADP-ribose] polymerase 2 (PARP2) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-BP866224HUg6 | Recombinant Human Poly [ADP-ribose] polymerase 2 (PARP2) | Baculovirus |
| CSB-EP866224HU1 | Recombinant Human Poly [ADP-ribose] polymerase 2 (PARP2), partial | E.coli |
| CSB-EP866224HU | Recombinant Human Poly [ADP-ribose] polymerase 2 (PARP2) | E.coli |
| CSB-BP866224HU | Recombinant Human Poly [ADP-ribose] polymerase 2 (PARP2) | Baculovirus |
