PBK
PBK，全稱為PDZ結(jié)合激酶（PDZ-binding kinase），也被稱為TOPK（T-lymphokine-activated killer cell-originated protein kinase）。該蛋白在細(xì)胞增殖和細(xì)胞周期進(jìn)程中發(fā)揮重要作用，與多種疾病的發(fā)生發(fā)展密切相關(guān)。近年來，研究發(fā)現(xiàn)PBK蛋白在薄型內(nèi)膜疾病中表達(dá)顯著下降，可能成為診斷和治療該疾病的潛在靶點(diǎn)。此外，PBK蛋白還在肝細(xì)胞癌中表現(xiàn)出作為生物標(biāo)志物的價(jià)值，其表達(dá)水平與腫瘤的進(jìn)展和免疫微環(huán)境密切相關(guān)。目前，針對(duì)PBK蛋白的藥物研發(fā)也在積極推進(jìn)中，例如Pharmbio Korea Co Ltd研發(fā)的小分子藥物PBK-1801正處于臨床研究階段。這些研究為PBK蛋白相關(guān)疾病的治療提供了新的思路和策略。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PBK Antibody (CSB-PA822241DSR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: PBK antibody at 6μg/ml
Lane 1: Hela whole cell lysate
Lane 2: Mouse gonad tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 37, 38 kDa
Observed band size: 37 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA822241DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA822241DSR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human thymus tissue using CSB-PA822241DSR1HU at dilution of 1:100
PBK Antibodies
PBK for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA017500GA01HU | PBK Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA822241DSR1HU | PBK Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA030267 | Phospho-PBK (T9) Antibody | Human | WB, IHC, ELISA |
| CSB-PA030268 | PBK Antibody | Human,Monkey | WB, IHC, ELISA |
PBK Proteins
PBK Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP822241HU CSB-BP822241HU CSB-MP822241HU CSB-EP822241HU-B |
Recombinant Human Lymphokine-activated killer T-cell-originated protein kinase (PBK) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP822241HU | Recombinant Human Lymphokine-activated killer T-cell-originated protein kinase (PBK) | E.coli |
| CSB-EP822241HUb0 | Recombinant Human Lymphokine-activated killer T-cell-originated protein kinase (PBK) | E.coli |
