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PDE5A

PDE5A,即磷酸二酯酶5A,別名cGMP-binding cGMP-specific phosphodiesterase、CGB-PDE。它是磷酸二酯酶家族中的一員,主要在心血管系統(tǒng)和中樞神經(jīng)系統(tǒng)中發(fā)揮作用。它通過水解cGMP(環(huán)磷酸鳥苷)和cAMP(環(huán)磷酸腺苷),調(diào)節(jié)細(xì)胞內(nèi)信號傳導(dǎo),影響血管舒張、血小板功能和神經(jīng)傳遞。PDE5A的活性與多種疾病相關(guān),包括心血管疾病、性功能障礙和某些類型的癌癥。PDE5A抑制劑,如西地那非,被用于治療勃起功能障礙和肺動脈高壓,同時,它們還可能在神經(jīng)保護(hù)和抗癌領(lǐng)域發(fā)揮作用。因此,PDE5A是藥物開發(fā)和疾病治療中的一個關(guān)鍵靶點。

熱銷產(chǎn)品

Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) , partial (CSB-YP524921HU)

驗證數(shù)據(jù)

CSB-YP524921HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PDE5A Antibody (CSB-PA126186)

驗證數(shù)據(jù)

CSB-PA126186

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA126186(PDE5A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA126186

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA126186(PDE5A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

CSB-PA126186

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA126186(PDE5A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes

PDE5A Antibodies

PDE5A for Homo sapiens (Human)

PDE5A Proteins

PDE5A Proteins for Rattus norvegicus (Rat)

PDE5A Proteins for Homo sapiens (Human)

PDE5A Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

PDE5A Proteins for Bos taurus (Bovine)

PDE5A Proteins for Mus musculus (Mouse)