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PEAR1

PEAR1,即血小板內(nèi)皮聚集受體1,別名platelet endothelial aggregation receptor 1。這是一種主要在血小板和內(nèi)皮細胞上表達的跨膜受體,由23個外顯子和22個內(nèi)含子組成。PEAR1在血小板的活化和聚集過程中起著重要作用,參與多種血管相關(guān)疾病的發(fā)生發(fā)展。PEAR1的作用機制涉及與血小板表面的未知配體結(jié)合,介導血小板活化信號,以及調(diào)控內(nèi)皮細胞功能和介導血小板與內(nèi)皮細胞的相互作用。PEAR1對維持血管健康穩(wěn)態(tài)、血管損傷修復、調(diào)節(jié)血管內(nèi)皮功能具有重要作用。此外,PEAR1基因的多態(tài)性與血小板聚集能力以及血管功能有著密切的關(guān)系,是心血管疾病治療的潛在靶點。

熱銷產(chǎn)品

PEAR1 Antibody (CSB-PA017765LA01HU)

驗證數(shù)據(jù)

CSB-PA017765LA01HU

Western Blot
Positive WB detected in: Rat liver tissue, Mouse kidney tissue
All lanes: PEAR1 antibody at 5.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 111 kDa
Observed band size: 111 kDa

CSB-PA017765LA01HU

IHC image of CSB-PA017765LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA017765LA01HU

Immunofluorescence staining of U251 cells with CSB-PA017765LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PEAR1 Antibodies

PEAR1 for Homo sapiens (Human)

PEAR1 Proteins

PEAR1 Proteins for Homo sapiens (Human)