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PGLYRP1

肽聚糖識別蛋白1(PGLYRP1)是一種先天性免疫系統(tǒng)的重要效應(yīng)分子,也被稱為PGRP-S或Tag7。該蛋白能夠特異性識別細(xì)菌細(xì)胞壁的肽聚糖成分,通過直接結(jié)合病原微生物觸發(fā)殺菌活性,例如誘導(dǎo)溶菌酶釋放或破壞細(xì)菌膜結(jié)構(gòu)。其功能不依賴傳統(tǒng)免疫細(xì)胞介導(dǎo),在皮膚、呼吸道和腸道等屏障組織中廣泛表達(dá),構(gòu)成人體抵御感染的第一道防線。
PGLYRP1的表達(dá)異常與多種炎癥性疾病相關(guān)。在類風(fēng)濕性關(guān)節(jié)炎患者的關(guān)節(jié)滑液中可檢測到該蛋白水平升高,其促炎特性可能加劇關(guān)節(jié)損傷。相反,銀屑病和炎癥性腸病患者病灶部位常出現(xiàn)PGLYRP1表達(dá)下調(diào),提示其免疫調(diào)節(jié)功能的缺失。近年來,基于該蛋白的雙向調(diào)控特性,科學(xué)家正探索其在膿毒癥和癌癥中的治療潛力。例如,利用重組PGLYRP1增強(qiáng)抗生素療效的研究已進(jìn)入臨床前階段,而針對其促癌轉(zhuǎn)移活性的單抗藥物也在開發(fā)中,為免疫相關(guān)疾病提供了新的干預(yù)思路。

熱銷產(chǎn)品

Recombinant Human Peptidoglycan recognition protein 1 (PGLYRP1) (CSB-EP017862HU)

驗(yàn)證數(shù)據(jù)

CSB-EP017862HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PGLYRP1 Antibody (CSB-PA017862LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA017862LA01HU

IHC image of CSB-PA017862LA01HU diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA017862LA01HU

IHC image of CSB-PA017862LA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

PGLYRP1 Antibodies

PGLYRP1 for Homo sapiens (Human)

PGLYRP1 Proteins

PGLYRP1 Proteins for Homo sapiens (Human)