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PLK1

PLK1(Polo樣激酶1)是調(diào)控細(xì)胞分裂的關(guān)鍵蛋白,屬于絲氨酸/蘇氨酸激酶家族。該蛋白通過磷酸化下游靶點(diǎn)驅(qū)動(dòng)有絲分裂進(jìn)程,確保染色體精準(zhǔn)分離和胞質(zhì)分裂完成。研究發(fā)現(xiàn),PLK1在多種惡性腫瘤中異常高表達(dá),其活性失控會(huì)導(dǎo)致基因組不穩(wěn)定性,促進(jìn)腫瘤增殖與轉(zhuǎn)移,尤其在乳腺癌、肺癌和結(jié)直腸癌中與預(yù)后不良相關(guān)。針對(duì)這一靶點(diǎn),全球已開發(fā)出BI 2536、Volasertib等小分子抑制劑,其中Volasertib聯(lián)合化療在急性髓系白血病II期試驗(yàn)中顯示出生存期延長,但因心臟毒性未獲FDA批準(zhǔn)。近年來研究者嘗試通過聯(lián)合用藥策略降低毒副作用,同時(shí)探索PLK1與PARP抑制劑在DNA損傷修復(fù)中的協(xié)同效應(yīng),為實(shí)體瘤治療開辟新方向。我國正大天晴等企業(yè)也在推進(jìn)同類藥物的臨床試驗(yàn)。

熱銷產(chǎn)品

Recombinant Human Serine/threonine-protein kinase PLK1 (PLK1) (CSB-BP018193HU)

驗(yàn)證數(shù)據(jù)

CSB-BP018193HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PLK1 Antibody (CSB-PA018193LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA018193LA01HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA018193LA01HU at dilution of 1:100

CSB-PA018193LA01HU

Immunofluorescence staining of A549 cells with CSB-PA018193LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

PLK1 Antibodies

PLK1 for Homo sapiens (Human)

PLK1 Proteins

PLK1 Proteins for Homo sapiens (Human)

PLK1 Proteins for Xenopus laevis (African clawed frog)

PLK1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

PLK1 Proteins for Bos taurus (Bovine)

PLK1 Proteins for Rattus norvegicus (Rat)