POGK
POGK，別名BASS2、KRBOX2、LST003。POGK由人類POGK基因編碼，該基因位于1號(hào)染色體的1q24.1區(qū)域。POGK編碼的蛋白質(zhì)在N端包含一個(gè)KRAB結(jié)構(gòu)域，在C端包含一個(gè)轉(zhuǎn)座酶結(jié)構(gòu)域，表明它可能屬于人類DNA介導(dǎo)的轉(zhuǎn)座子家族。POGK的作用機(jī)制涉及與轉(zhuǎn)錄共阻遏物TRIM28結(jié)合，直接抑制核心核糖體蛋白的轉(zhuǎn)錄，從而全面抑制核糖體生物學(xué)功能，限制三陰性乳腺癌細(xì)胞的生長。POGK作為一種轉(zhuǎn)座元件衍生基因，在腫瘤發(fā)生與發(fā)展中發(fā)揮著關(guān)鍵作用，特別是在乳腺癌中，POGK的表達(dá)變化尤為顯著。POGK通過抑制核糖體基因的表達(dá)、初始蛋白質(zhì)的合成，進(jìn)而抑制三陰性乳腺癌細(xì)胞的生長，因此POGK有望成為潛在的腫瘤治療靶點(diǎn)。
熱銷產(chǎn)品
POGK Antibody (CSB-PA018298LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018298LA01HU at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA018298LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
POGK Antibodies
POGK for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA018298LA01HU | POGK Antibody | Human | ELISA, IHC, IF |
| CSB-PA018298LB01HU | POGK Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018298LC01HU | POGK Antibody, FITC conjugated | Human | |
| CSB-PA018298LD01HU | POGK Antibody, Biotin conjugated | Human | ELISA |
POGK Proteins
POGK Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP018298HU CSB-EP018298HU CSB-BP018298HU CSB-MP018298HU CSB-EP018298HU-B |
Recombinant Human Pogo transposable element with KRAB domain (POGK) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
