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PRKACA

PRKACA,cAMP-dependent protein kinase catalytic subunit alpha,別名PKCA1、Cs-PKA等。PRKACA是蛋白激酶A(PKA)的α催化亞基,PKA是一種由cAMP激活的絲氨酸/蘇氨酸蛋白激酶,由兩個催化亞基和兩個調節(jié)亞基組成。在沒有cAMP時,PKA以鈍化復合體形式存在。cAMP與調節(jié)亞基結合后,導致調節(jié)亞基構象變化,使調節(jié)亞基和催化亞基解離,釋放出催化亞基,進而使細胞內(nèi)某些蛋白的絲氨酸或蘇氨酸殘基磷酸化,改變這些蛋白的活性,影響相關基因的表達。PRKACA參與調節(jié)多種細胞功能,包括糖原、糖和脂質的代謝,以及晝夜睡眠/覺醒周期、快速眼動睡眠等生理過程。PRKACA的異?;钚耘c多種疾病相關,如腎上腺皮質腺瘤、充血性心力衰竭和原發(fā)性色素性結節(jié)性腎上腺皮質疾病。

熱銷產(chǎn)品

Recombinant Human cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) (CSB-EP018688HU)

驗證數(shù)據(jù)

CSB-EP018688HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

PRKACA Antibody (CSB-PA018688LA01HU)

驗證數(shù)據(jù)

CSB-PA018688LA01HU

Western Blot
Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate
All lanes: PRKACA antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 40 kDa
Observed band size: 41 kDa

CSB-PA018688LA01HU

IHC image of CSB-PA018688LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA018688LA01HU

IHC image of CSB-PA018688LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

PRKACA Antibodies

PRKACA for Homo sapiens (Human)

PRKACA Proteins

PRKACA Proteins for Homo sapiens (Human)

PRKACA Proteins for Rattus norvegicus (Rat)

PRKACA Proteins for Sus scrofa (Pig)

PRKACA Proteins for Mus musculus (Mouse)

PRKACA Proteins for Bos taurus (Bovine)

PRKACA Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

PRKACA Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

PRKACA Proteins for Ovis aries (Sheep)

PRKACA Proteins for Canis lupus familiaris (Dog) (Canis familiaris)