PTGER4，全稱為前列腺素E受體4（亞型EP4），是一種在人體內(nèi)發(fā)揮重要作用的蛋白質(zhì)。該蛋白屬于G蛋白偶聯(lián)受體家族，能夠與前列腺素E2（PGE2）結(jié)合，從而參與多種生理和病理過程。PTGER4的常見別名包括EP4、EP4R、Ptger、PTGER2、PTGER4和Ptgerep4等。
PTGER4蛋白在人體內(nèi)的主要功能是作為PGE2的受體，介導(dǎo)PGE2引發(fā)的細(xì)胞信號(hào)傳導(dǎo)。研究表明，PTGER4激動(dòng)劑能夠刺激胰島α和β細(xì)胞分泌胰高血糖素和胰島素，對(duì)血糖調(diào)節(jié)具有重要作用。此外，PTGER4還參與調(diào)節(jié)腎血流動(dòng)力學(xué)、腸道上皮細(xì)胞轉(zhuǎn)運(yùn)、腎上腺醛固酮分泌以及子宮功能等。
PTGER4蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)。例如，研究表明PTGER4激動(dòng)劑能夠促進(jìn)胰島α和β細(xì)胞分泌胰高血糖素和胰島素，對(duì)糖尿病的治療具有潛在價(jià)值。此外，PTGER4還與骨質(zhì)疏松癥、皮膚免疫應(yīng)答等疾病相關(guān)。

熱銷產(chǎn)品

PTGER4 Antibody (CSB-PA018973LA01HU)

驗(yàn)證數(shù)據(jù)

Western Blot
Positive WB detected in: Rat liver tissue, Rat kidney tissue
All lanes: PTGER4 antibody at 3.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 54 kDa
Observed band size: 54 kDa

Immunofluorescence staining of HepG2 cells with CSB-PA018973LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).