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PTGS2

PTGS2,即前列腺素內(nèi)過(guò)氧化物合酶2,也被稱(chēng)為環(huán)氧化酶2(Cyclooxygenase-2,COX-2)。它是一種在多種細(xì)胞類(lèi)型中表達(dá)的酶,尤其在炎癥和組織損傷時(shí)表達(dá)水平上升。PTGS2的作用機(jī)制是通過(guò)催化花生四烯酸轉(zhuǎn)化為前列腺素H2,進(jìn)而參與多種生理和病理過(guò)程,包括炎癥反應(yīng)、疼痛感知、發(fā)熱以及血小板聚集等。PTGS2激活的信號(hào)通路涉及NMDA受體依賴(lài)的神經(jīng)遞質(zhì)釋放、細(xì)胞增殖和細(xì)胞存活等。在生物學(xué)意義上,PTGS2不僅在維持正常生理功能中發(fā)揮作用,而且在腫瘤發(fā)展、神經(jīng)損傷和炎癥性疾病中具有重要作用。其異常表達(dá)與多種疾病包括癌癥、神經(jīng)退行性疾病和心血管疾病等有關(guān),是許多病理過(guò)程中的關(guān)鍵調(diào)控點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human Prostaglandin G/H synthase 2 (PTGS2), partial (CSB-EP018986HU)

驗(yàn)證數(shù)據(jù)

CSB-EP018986HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CSB-EP018986HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP018986HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) PTGS2.

CSB-EP018986HU

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP018986HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) PTGS2.

PTGS2 Recombinant Monoclonal Antibody (CSB-RA920283A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA920283A0HU

Western Blot
Positive WB detected in: U-87 whole cell lysate
All lanes: COX2 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69 kDa
Observed band size: 69 kDa

CSB-RA920283A0HU

Immunofluorescence staining of HepG2 Cells with CSB-RA920283A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

PTGS2 Antibodies

PTGS2 for Homo sapiens (Human)

PTGS2 for H, M, R

PTGS2 Proteins

PTGS2 Proteins for Ovis aries (Sheep)

PTGS2 Proteins for Cavia porcellus (Guinea pig)

PTGS2 Proteins for Homo sapiens (Human)

PTGS2 Proteins for Gallus gallus (Chicken)

PTGS2 Proteins for Oryctolagus cuniculus (Rabbit)

PTGS2 Proteins for Equus caballus (Horse)

PTGS2 Proteins for Bos taurus (Bovine)

PTGS2 Proteins for Mustela vison (American mink) (Neovison vison)

PTGS2 Proteins for Rattus norvegicus (Rat)

PTGS2 ELISA Kit

PTGS2 ELISA Kit for Homo sapiens (Human)

PTGS2 ELISA Kit for Mus musculus (Mouse)

PTGS2 ELISA Kit for Rattus norvegicus (Rat)