PVALB
PVALB，即小清蛋白（Parvalbumin）。它是一種低分子量的鈣結(jié)合蛋白，分子量大約在10-12.5 kDa之間，結(jié)構(gòu)上與鈣調(diào)蛋白和肌鈣蛋白C有關(guān)。PVALB在快肌纖維中的含量特別高，但也在其他組織和器官如魚類的大腦和生殖腺中表達。PVALB的作用機制涉及調(diào)節(jié)肌肉中的鈣離子轉(zhuǎn)換，特別是在快肌纖維中，它幫助控制肌肉收縮的速度和力度。在生物學(xué)意義上，PVALB在多種生物過程中發(fā)揮作用，包括神經(jīng)遞質(zhì)釋放、肌肉收縮以及作為魚類中的主要過敏原。超過95%的魚類引起的食品過敏是由PVALB蛋白引起的。此外，PVALB還可能作為肥胖治療的潛在新靶點，通過影響M2型巨噬細胞來調(diào)節(jié)能量消耗和產(chǎn)熱。
熱銷產(chǎn)品
● Recombinant Mouse Parvalbumin alpha (Pvalb)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據(jù)
Immunofluorescence staining of U251 cells with CSB-PA019092HA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Western Blot
Positive WB detected in: Mouse brain tissue, Mouse kidney tissue
All lanes: PVALB antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 13 kDa
Observed band size: 13 kDa
Immunofluorescent analysis of HepG2 cells using CSB-PA019092HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA019092HA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA019092HA01HU at dilution of 1:100
PVALB Antibodies
PVALB for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA019092HA01HU | PVALB Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA263723 | PVALB Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA648142 | PVALB Antibody | Human,Mouse,Rat | ELISA,WB |
PVALB Proteins
PVALB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP019092HU CSB-BP019092HU CSB-MP019092HU CSB-EP019092HU-B |
Recombinant Human Parvalbumin alpha (PVALB) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP019092HU | Recombinant Human Parvalbumin alpha (PVALB) | E.coli |
