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RET

RET是受體酪氨酸激酶家族的一員,其結(jié)構(gòu)包含細(xì)胞外域、跨膜域、酪氨酸激酶域和羧基末端。RET通過與特定配體結(jié)合,激活其胞內(nèi)區(qū)的酪氨酸激酶活性,進(jìn)而啟動(dòng)下游信號(hào)轉(zhuǎn)導(dǎo)通路,影響細(xì)胞的生長(zhǎng)、增殖、分化和凋亡等生物學(xué)過程。RET在維持多種細(xì)胞類型如神經(jīng)細(xì)胞、內(nèi)分泌細(xì)胞和腎臟細(xì)胞的正常功能中發(fā)揮著重要作用。然而,當(dāng)RET基因發(fā)生突變或異常表達(dá)時(shí),可能導(dǎo)致疾病的發(fā)生,如甲狀腺髓樣癌等。因此,對(duì)RET的結(jié)構(gòu)、功能和生物學(xué)作用的研究不僅有助于我們理解其在正常生理過程中的作用,也為相關(guān)疾病的預(yù)防和治療提供了新的視角和策略。

熱銷產(chǎn)品

RET Recombinant Monoclonal Antibody (CSB-RA288083A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA288083A0HU

Overlay histogram showing Hela cells stained with CSB-RA288083A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃.The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 30min at 4℃. Control antibody (green line) was Rabbit IgG (1μg/1*106 cells) used under the same conditions. Acquisition of >10,000 events was performed.

RET Antibodies

RET for Homo sapiens (Human)

RET Proteins

RET Proteins for Homo sapiens (Human)