ROBO4

ROBO4，全稱為Roundabout homolog 4，別名包括MRB、AOVD3和ECSM4。該蛋白主要表達于內(nèi)皮細胞，參與血管生成和內(nèi)皮屏障的建立，并位于細胞外外體泡中。ROBO4與主動脈瓣疾病3相關(guān)，其突變可能導致主動脈瓣畸形、狹窄和升主動脈瘤等病癥。此外，ROBO4還參與調(diào)控心臟系統(tǒng)靜脈回流和心包膜的發(fā)育，其缺失會導致小鼠發(fā)育過程中的腎臟缺失和輸尿管發(fā)育不全。ROBO4蛋白通過與SLIT2蛋白結(jié)合，發(fā)揮抑制細胞間粘附介導活性的作用，從而穩(wěn)定血管通透性和完整性。目前，針對ROBO4蛋白的藥物研發(fā)尚處于探索階段，但其在心血管疾病和腎臟疾病治療方面具有潛在的應用價值。

熱銷產(chǎn)品

Recombinant Human Roundabout homolog 4 (ROBO4),?partial (CSB-EP845177HU1d7)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ROBO4 Antibody (CSB-PA903544)

驗證數(shù)據(jù)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA903544(ROBO4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA903544(ROBO4 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)

Human Roundabout homolog 4(ROBO4) ELISA kit (CSB-EL020057HU)

驗證數(shù)據(jù)

貨號：CSB-EL020057HU

規(guī)格：96T/48T

靈敏度：15.6 pg/mL

檢測范圍：62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

ROBO4 Antibody

ROBO4 Protein

ROBO4 ELISA Kit

ROBO4 Antibodies

ROBO4 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA020057GA01HU	ROBO4 Antibody	Human,Mouse	ELISA,WB
CSB-PA121728	ROBO4 Antibody	Human	ELISA,IHC
CSB-PA903544	ROBO4 Antibody	Human	ELISA,IHC
CSB-PA845177ESR2HU	ROBO4 Antibody	Human	ELISA, IHC

ROBO4 Proteins

ROBO4 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP845177HU CSB-EP845177HU CSB-BP845177HU CSB-MP845177HU CSB-EP845177HU-B	Recombinant Human Roundabout homolog 4 (ROBO4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP845177HU1d7	Recombinant Human Roundabout homolog 4 (ROBO4),?partial	E.coli