ROR1
ROR1,即受體酪氨酸激酶樣孤兒受體1,別名Neurotrophic tyrosine kinase, receptor-related 1。它是一種I型跨膜蛋白,屬于受體酪氨酸激酶(RTKs)家族成員之一。ROR1在人正常組織中低表達(dá)或不表達(dá),但在多種惡性腫瘤或組織中高度表達(dá),如慢性淋巴細(xì)胞白血?。–LL)、乳腺癌、卵巢癌、黑色素瘤、肺腺癌等。ROR1的作用機(jī)制涉及介導(dǎo)非經(jīng)典的Wnt信號通路,尤其是Wnt5a,參與NF-κB亞基p65的磷酸化,激活腫瘤細(xì)胞中NF-κB通路,促進(jìn)細(xì)胞遷移和侵襲。作為一種具有高度識別性的腫瘤特異性標(biāo)志物,ROR1已成為腫瘤治療中一個潛在極具吸引力的靶點(diǎn)。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized ROR1 at 2 μg/ml can bind anti-ROR1 antibody(CSB-RA020067A1HU), the EC50 is 0.2450-0.3416 ng/mL.

The purity of ROR1 was greater than 90% as determined by SEC-HPLC
ROR1 Recombinant Monoclonal Antibody (CSB-RA020067A1HU)
驗(yàn)證數(shù)據(jù)

The Binding Activity of ROR1 with Anti-ROR1 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human ROR1(CSB-MP020067HU1d7) at 2 μg/mL can bind Anti-ROR1 recombinant antibody, the EC50 is 0.2450-0.3416 ng/mL.

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
ROR1 Antibodies
ROR1 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA020067LC01HU | ROR1 Antibody, FITC conjugated | Human | |
CSB-PA020067GA01HU | ROR1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA067964 | ROR1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA993257 | ROR1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA020067LA01HU | ROR1 Antibody | Human | ELISA, IHC |
CSB-RA020067A1HU | ROR1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
ROR1 Proteins
ROR1 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP020067HU | Recombinant Human Tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial | Yeast |
CSB-EP020067HU | Recombinant Human Tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial | E.coli |
CSB-MP020067HU1d7 | Recombinant Human Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1), partial (Active) | Mammalian cell |