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RUVBL2

RUVBL2,別名RVB2、TIH2、ECP51、TIP48、CGI-46、ECP-51、INO80J、REPTIN、TIP49B、TAP54-beta,在人類細(xì)胞中廣泛表達(dá),屬于AAA+ATPase家族成員。RUVBL2的作用機(jī)制涉及其ATP酶活性,參與多種細(xì)胞過程,包括染色質(zhì)重塑、轉(zhuǎn)錄調(diào)控、葡萄糖轉(zhuǎn)運(yùn)以及大分子復(fù)合物的組裝。RUVBL2還起到轉(zhuǎn)錄調(diào)控的作用,通過調(diào)節(jié)與軸突生成和突觸小泡相關(guān)的基因表達(dá)來調(diào)控突觸可塑性和突觸傳遞,進(jìn)而影響食欲和體重控制。RUVBL2與多種疾病相關(guān),包括脊髓性肌肉萎縮、遠(yuǎn)端遺傳性運(yùn)動(dòng)神經(jīng)元病、先天性角化不良等。

熱銷產(chǎn)品

Recombinant Human RuvB-like 2 (RUVBL2) (CSB-EP897459HU)

驗(yàn)證數(shù)據(jù)

CSB-EP897459HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

RUVBL2 Antibody (CSB-PA897459LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA897459LA01HU

Western Blot
Positive WB detected in: K562 whole cell lysate, HepG2 whole cell lysate, Rat liver tissue, Mouse brain tissue
All lanes: RUVBL2 antibody at 2.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52, 47 kDa
Observed band size: 52 kDa

CSB-PA897459LA01HU

IHC image of CSB-PA897459LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA897459LA01HU

IHC image of CSB-PA897459LA01HU diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

RUVBL2 Antibodies

RUVBL2 for Homo sapiens (Human)

RUVBL2 Proteins

RUVBL2 Proteins for Homo sapiens (Human)