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SEMA4D

SEMA4D是一種跨膜蛋白,包括一個胞外區(qū)域、一個跨膜區(qū)域和一個胞漿區(qū)域。它的胞外區(qū)域包含Semaphorin結構域,用于與其他蛋白質(zhì)相互作用,觸發(fā)信號傳導。 SEMA4D在神經(jīng)發(fā)育中發(fā)揮關鍵作用。它參與了神經(jīng)軸突的引導和突觸形成。通過與其受體(如Plexin家族受體)的相互作用,SEMA4D可以影響神經(jīng)元的生長和連接。SEMA4D也在免疫系統(tǒng)中具有重要作用。它可以調(diào)節(jié)免疫細胞的活化和遷移。SEMA4D和其受體(如CD72和Plexin B2)之間的相互作用可以影響T細胞、B細胞和巨噬細胞的功能。SEMA4D是一個多功能的分子,在神經(jīng)發(fā)育、免疫系統(tǒng)和疾病中都發(fā)揮作用。研究SEMA4D的功能和調(diào)控機制有助于我們更好地理解神經(jīng)發(fā)育和免疫應答的調(diào)控,同時也有助于開發(fā)新的治療方法,尤其是在癌癥等疾病領域。

更多相關閱讀:新興SEMA4D抑制劑嶄露頭角,克服免疫治療耐藥難題?

熱銷產(chǎn)品

蛋白

Recombinant Human Semaphorin-4D(SEMA4D),partial (Active) CSB-MP835707HU

驗證數(shù)據(jù)

SDS
CSB-MP835707HU SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP835707HU

Activity: Measured by its binding ability in a functional ELISA. Immobilized human SEMA4D at 2 μg/ml can bind Pepinemab, the EC50 is 4.035-5.743 ng/mL.

Recombinant Mouse Semaphorin-4D(Sema4d),partial (Active) CSB-MP020990MO

驗證數(shù)據(jù)

SDS
CSB-MP020990MO SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP020990MO

Activity: Measured by its binding ability in a functional ELISA. Immobilized Pepinemab at 2 μg/ml can bind Mouse Sema4d, the EC50 is 4.878-7.446 ng/ml.

Recombinant Human Semaphorin-4D(SEMA4D),partial (Active) CSB-MP835707HUd9

驗證數(shù)據(jù)

SDS
CSB-MP835707HUd9 SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP835707HUd9

Activity: Measured by its binding ability in a functional ELISA. Immobilized human SEMA4D at 2 μg/ml can bind biotinylated Pepinemab, the EC50 is 1.005-1.776 ng/mL.

ELISA
High Purity Validated of CSB-MP835707HUd9

Activity: Measured by its binding ability in a functional ELISA. Immobilized human SEMA4D at 5 μg/ml can bind human PLXNB1 (CSB-MP018222HU2k6), the EC50 is 0.8179-1.357 μg/mL.

Recombinant Macaca mulatta Semaphorin-4D isoform 1(SEMA4D),partial (Active) CSB-MP3947MOW

驗證數(shù)據(jù)

SDS
CSB-MP3947MOW SDS

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

ELISA
High Purity Validated of CSB-MP3947MOW

Activity: Measured by its binding ability in a functional ELISA. Immobilized Rhesus macaque SEMA4D at 2 μg/mL can bind Anti-SEMA4D recombinant antibody (CSB-RA835707A1HU), the EC50 is 1.943-2.724 ng/mL.


抗體

SEMA4D Recombinant Monoclonal Antibody CSB-RA835707A2HU

驗證數(shù)據(jù)

SDS
High Purity Validated of CSB-RA835707A2HU

The Binding Activity of Mouse Sema4d with Anti-SEMA4D recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Anti-SEMA4D recombinant antibody at 2 μg/mL can bind Mouse Sema4d (CSB-MP020990MO), the EC50 is 5.829-16.86 ng/mL.

ELISA
High Purity Validated of CSB-RA835707A2HU

The Binding Activity of Human SEMA4D with Anti-SEMA4D recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SEMA4D (CSB-MP835707HU) at 2 μg/mL can bind Anti- SEMA4D recombinant antibody, the EC50 is 60.38-152.6 ng/mL.

FC
CSB-RA835707A2HU-FC

Untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) were stained with anti-SEMA4D antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

SEMA4D Recombinant Monoclonal Antibody CSB-RA835707A1HU

驗證數(shù)據(jù)

FC
CSB-RA835707A1HU FC

Untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) were stained with anti-SEMA4D antibody (2μg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

ELISA
High Purity Validated of CSB-RA835707A1HU

The Binding Activity of Mouse Sema4d with Anti-SEMA4D recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Sema4d (CSB-MP020990MO) at 2 μg/mL can bind Anti-SEMA4D recombinant antibody, the EC50 is 98.14-174.8 ng/mL.

ELISA
High Purity Validated of CSB-RA835707A1HU

The Binding Activity of Human SEMA4D with Anti-SEMA4D recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SEMA4D (CSB-MP835707HU) at 2 μg/mL can bind Anti-SEMA4D recombinant antibody, the EC50 is 1.082-4.805 ng/mL.


細胞株

HEK293T/Human SEMA4D Stable Cell Line CSB-SC835707HU

驗證數(shù)據(jù)

FC
CSB-SC0005HU-FACS

Untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) were stained with anti-SEMA4D antibody (CSB-RA835707A2HU) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

SEMA4D Antibodies

SEMA4D for Homo sapiens (Human)

SEMA4D Proteins

SEMA4D Proteins for Mus musculus (Mouse)

SEMA4D Proteins for Homo sapiens (Human)

SEMA4D Proteins for Gallus gallus (Chicken)

SEMA4D ELISA Kit

SEMA4D ELISA Kit for Homo sapiens (Human)