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SIRPB1

SIRPB1,全稱為信號(hào)調(diào)節(jié)蛋白β1,常見別名包括CD172b和SIRP-BETA-1。該蛋白屬于免疫球蛋白超家族,參與多種細(xì)胞信號(hào)傳導(dǎo)過程。SIRPB1通過與CD47蛋白相互作用,調(diào)節(jié)細(xì)胞增殖、凋亡和免疫應(yīng)答等生物學(xué)功能。研究表明,SIRPB1在腦部衰老過程中發(fā)揮重要作用,其表達(dá)水平與大腦年齡差距相關(guān)。此外,SIRPB1還與某些神經(jīng)退行性疾病有關(guān),如阿爾茨海默病和帕金森病。在藥物研發(fā)方面,針對(duì)SIRPB1的抗體藥物已進(jìn)入臨床試驗(yàn)階段,用于治療自身免疫病和炎性疾病。此外,SIRPB1也被視為抗衰老藥物研發(fā)的潛在靶點(diǎn),相關(guān)研究正在深入進(jìn)行中。

熱銷產(chǎn)品

Recombinant Human Signal-regulatory protein beta-1 (SIRPB1), partial (CSB-MP021335HU)

驗(yàn)證數(shù)據(jù)

CSB-MP021335HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SIRPB1 Antibody (CSB-PA021335LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA021335LA01HU

Immunofluorescence staining of U251 cell with CSB-PA021335LA01HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA021335LA01HU

Immunofluorescence staining of U251 cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA021335LA01HU

Western Blot
Positive WB detected in: THP-1 whole cell lysate(20μg), U87 whole cell lysate(20μg), A549 whole cell lysate(20μg), PC-3 whole cell lysate(20μg)
All lanes: SIRPB1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 43,19 kDa
Observed band size: 43,86 kDa
Exposure time: 120s

CSB-PA021335LA01HU

Immunofluorescence staining of Hela cell with CSB-PA021335LA01HU at 1:10, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-PA021335LA01HU

Immunofluorescence staining of Hela cell with 5% goat serum, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SIRPB1 Antibodies

SIRPB1 for Homo sapiens (Human)

SIRPB1 Proteins

SIRPB1 Proteins for Homo sapiens (Human)