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SIRT1

SIRT1,即細(xì)胞衰老相關(guān)蛋白1,別名Sirtuin 1、NAD依賴性去乙酰化酶1等。SIRT1是一種由SIRT1基因編碼的蛋白質(zhì),屬于Sirtuin家族成員之一,主要在細(xì)胞核中發(fā)揮作用。它是一種依賴于煙酰胺腺嘌呤二核苷酸(NAD+)的去乙酰化酶,通過(guò)去除蛋白質(zhì)上的乙?;鶊F(tuán)來(lái)調(diào)控多種細(xì)胞過(guò)程,包括細(xì)胞代謝、應(yīng)激反應(yīng)、細(xì)胞周期和衰老。SIRT1的作用機(jī)制涉及到對(duì)多種底物蛋白的去乙酰化修飾,這些底物包括但不限于組蛋白、轉(zhuǎn)錄因子、DNA修復(fù)蛋白和信號(hào)傳導(dǎo)分子。SIRT1在生物學(xué)上的意義非常廣泛,它參與調(diào)節(jié)多種細(xì)胞生理過(guò)程和代謝途徑。SIRT1通過(guò)去乙?;饔脜⑴c調(diào)控細(xì)胞的能量代謝,促進(jìn)細(xì)胞對(duì)應(yīng)激的適應(yīng)性,保護(hù)細(xì)胞免受氧化損傷。此外,SIRT1還參與調(diào)節(jié)細(xì)胞周期和細(xì)胞衰老過(guò)程,影響細(xì)胞的增殖和分化。SIRT1的功能異常與多種疾病的發(fā)生發(fā)展有關(guān),包括代謝性疾病、神經(jīng)退行性疾病、心血管疾病和癌癥。因此,SIRT1是藥物開(kāi)發(fā)和疾病治療中的一個(gè)潛在靶點(diǎn),其激動(dòng)劑和抑制劑的研究正在積極進(jìn)行中。

熱銷產(chǎn)品

Recombinant Human NAD-dependent protein deacetylase sirtuin-1 (SIRT1) (CSB-EP822202HU)

驗(yàn)證數(shù)據(jù)

CSB-EP822202HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SIRT1 Recombinant Monoclonal Antibody (CSB-RA556800A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA556800A0HU

IHC image of CSB-RA556800A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

CSB-RA556800A0HU

Immunofluorescence staining of Hela Cells with CSB-RA556800A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

SIRT1 Antibodies

SIRT1 for Homo sapiens (Human)

SIRT1 Proteins

SIRT1 Proteins for Homo sapiens (Human)

SIRT1 Proteins for Mus musculus (Mouse)

SIRT1 ELISA Kit

SIRT1 ELISA Kit for Mus musculus (Mouse)

SIRT1 ELISA Kit for Homo sapiens (Human)