SIRT6

SIRT6全稱為沉默調(diào)節(jié)蛋白6，是sirtuin家族成員之一，因其依賴輔酶NAD+發(fā)揮去乙?；富钚?，又被稱作NAD依賴性組蛋白去乙?；?。SIRT6在基因組穩(wěn)定性維持和代謝調(diào)控中發(fā)揮核心作用，通過修復DNA損傷、調(diào)控糖脂代謝相關(guān)基因表達延緩細胞衰老進程。研究發(fā)現(xiàn)SIRT6缺失會引發(fā)早衰綜合征，其表達異常與肝癌、結(jié)腸癌等惡性腫瘤轉(zhuǎn)移密切相關(guān)，同時在Ⅱ型糖尿病、動脈粥樣硬化等代謝性疾病中呈現(xiàn)顯著下調(diào)趨勢。近年研究發(fā)現(xiàn)該蛋白可抑制NF-κB通路減輕慢性炎癥，并通過激活AMPK通路改善胰島素抵抗。當前針對SIRT6的藥物開發(fā)聚焦于小分子激活劑，如化合物MDL-800已在動物模型中證實可增強DNA修復能力并延長壽命，而部分天然產(chǎn)物如白藜蘆醇衍生物也顯示出調(diào)控潛力。隨著PROTAC等新技術(shù)的應用，靶向SIRT6的雙功能分子正成為抗衰老和癌癥治療領域的研究熱點。

熱銷產(chǎn)品

Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6) (CSB-EP854057HU)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SIRT6 Antibody (CSB-PA959450)

驗證數(shù)據(jù)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse stomach tissue, Primary antibody: CSB-PA959450(SIRT6 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds

SIRT6 Antibody

SIRT6 Protein

SIRT6 ELISA Kit

SIRT6 Antibodies

SIRT6 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA021344GA01HU	SIRT6 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA854057ESR2HU	SIRT6 Antibody	Human	ELISA
CSB-PA959450	SIRT6 Antibody	Human,Mouse	ELISA,WB
CSB-PA113703	SIRT6 Antibody	Human,Mouse	ELISA,WB

SIRT6 Proteins

SIRT6 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP021344MO CSB-EP021344MO CSB-BP021344MO CSB-MP021344MO CSB-EP021344MO-B	Recombinant Mouse NAD-dependent protein deacetylase sirtuin-6 (Sirt6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SIRT6 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP854057HU CSB-BP854057HU CSB-MP854057HU CSB-EP854057HU-B	Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP854057HU	Recombinant Human NAD-dependent protein deacetylase sirtuin-6 (SIRT6)	E.coli