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SLAMF7

SLAMF7,即信號(hào)淋巴細(xì)胞激活分子家族成員7。別名CD319、CS1、CRACC、19A2。它主要在免疫細(xì)胞和腫瘤細(xì)胞上表達(dá),包括自然殺傷細(xì)胞(NK細(xì)胞)、漿細(xì)胞等。SLAMF7的作用機(jī)制包括通過其分子結(jié)構(gòu)中的胞內(nèi)區(qū)富含酪氨酸的免疫受體轉(zhuǎn)換基序(ITSMs)參與信號(hào)傳導(dǎo),其中兩個(gè)保守酪氨酸Y281和Y261分別參與SLAMF7的激活和抑制信號(hào)通路。在腫瘤微環(huán)境中,SLAMF7可以通過調(diào)節(jié)NK細(xì)胞、單核/巨噬細(xì)胞等免疫細(xì)胞的活性,影響免疫細(xì)胞的抗腫瘤作用。例如,SLAMF7單克隆抗體——埃羅妥珠單抗(Elotuzumab)治療多發(fā)性骨髓瘤能夠誘導(dǎo)腫瘤微環(huán)境中表達(dá)SLAMF7的NK細(xì)胞、單核/巨噬細(xì)胞參與多發(fā)性骨髓瘤的抗腫瘤免疫過程。

熱銷產(chǎn)品

Recombinant Human SLAM family member 7 (SLAMF7), partial (CSB-EP021369HU)

驗(yàn)證數(shù)據(jù)

CSB-EP021369HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SLAMF7 Recombinant Monoclonal Antibody (CSB-RA021369MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA021369MA1HU

IHC image of CSB-RA021369MA1HU diluted at 1:200 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA021369MA1HU

Overlay Peak curve showing A549 cells surface stained with CSB-RA021369MA1HU (red line) at 1:200. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,023 events was performed.

SLAMF7 Antibodies

SLAMF7 for Homo sapiens (Human)

SLAMF7 Proteins

SLAMF7 Proteins for Homo sapiens (Human)

SLAMF7 Proteins for Mus musculus (Mouse)

SLAMF7 ELISA Kit

SLAMF7 ELISA Kit for Homo sapiens (Human)