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SLC1A5

SLC1A5全稱為溶質(zhì)載體家族1成員5,又稱ASCT2或ATB0,是一種中性氨基酸轉(zhuǎn)運(yùn)蛋白,主要負(fù)責(zé)谷氨酰胺、丙氨酸等氨基酸的跨膜運(yùn)輸。SLC1A5在腫瘤細(xì)胞中異常高表達(dá),尤其在依賴谷氨酰胺代謝的癌細(xì)胞中,通過維持細(xì)胞內(nèi)氨基酸平衡和能量供應(yīng),促進(jìn)腫瘤生長與增殖。SLC1A5活性與mTOR、Ras等調(diào)控細(xì)胞代謝與增殖的分子網(wǎng)絡(luò)密切相關(guān),在乳腺癌、肺癌、結(jié)直腸癌等多種惡性腫瘤中均觀察到表達(dá)水平升高。近年來,針對(duì)SLC1A5的抑制劑開發(fā)成為抗癌藥物研究熱點(diǎn),例如小分子化合物V-9302已進(jìn)入臨床前研究階段,通過阻斷谷氨酰胺攝取誘導(dǎo)癌細(xì)胞凋亡。SLC1A5還與神經(jīng)退行性疾病存在潛在關(guān)聯(lián),阿爾茨海默病患者腦脊液中ASCT2水平變化提示其可能參與神經(jīng)元代謝異常過程。當(dāng)前研究正探索將該蛋白作為生物標(biāo)志物或聯(lián)合治療靶點(diǎn)的可能性。

熱銷產(chǎn)品

SLC1A5 Recombinant Monoclonal Antibody (CSB-RA620892MA1HU)

驗(yàn)證數(shù)據(jù)

CSB-RA620892MA1HU

Immunofluorescence staining of MCF cell with CSB-RA620892MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).

CSB-RA620892MA1HU

Immunofluorescence staining of Hela cell with CSB-RA620892MA1HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Human IgG(H+L).

CSB-RA620892MA1HU

Overlay Peak curve showing A549 cells stained with CSB-RA620892MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

SLC1A5 Antibodies

SLC1A5 for Homo sapiens (Human)

SLC1A5 Proteins

SLC1A5 Proteins for Homo sapiens (Human)