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SLC2A2

SLC2A2,即溶質(zhì)載體家族2成員2,別名GLUT2。SLC2A2由人類SLC2A2基因編碼,該基因位于3號(hào)染色體的q26.1-q26.2區(qū)域。SLC2A2蛋白是一種質(zhì)膜糖蛋白,主要在肝臟、胰島β細(xì)胞、腸道和腎臟上皮中表達(dá)。這種蛋白質(zhì)介導(dǎo)了促進(jìn)雙向葡萄糖轉(zhuǎn)運(yùn)的過程,因其對(duì)葡萄糖的親和力較低,被認(rèn)為是葡萄糖的感應(yīng)器。SLC2A2的突變與包括Fanconi-Bickel綜合征和非胰島素依賴型糖尿病在內(nèi)的疾病相關(guān)。SLC2A2在調(diào)節(jié)葡萄糖穩(wěn)態(tài)中扮演著重要角色,參與腸道葡萄糖的攝取、腎臟的重吸收、胰島β細(xì)胞的感應(yīng),以及肝臟葡萄糖的攝取和釋放過程。

熱銷產(chǎn)品

SLC2A2 Recombinant Monoclonal Antibody (CSB-RA438622A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA438622A0HU

IHC image of CSB-RA438622A0HU diluted at 1:50 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.20% DAB.

CSB-RA438622A0HU

Immunofluorescence staining of HepG2 with CSB-RA438622A0HU at 1:25, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 495-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA438622A0HU

Overlay Peak curve showing HepG2 cells surface stained with CSB-RA438622A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

SLC2A2 Antibodies

SLC2A2 for Homo sapiens (Human)

SLC2A2 Proteins

SLC2A2 Proteins for Rattus norvegicus (Rat)

SLC2A2 Proteins for Homo sapiens (Human)

SLC2A2 Proteins for Mus musculus (Mouse)

SLC2A2 Proteins for Bos taurus (Bovine)

SLC2A2 Proteins for Sus scrofa (Pig)

SLC2A2 Proteins for Gallus gallus (Chicken)