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SLC5A5

SLC5A5,全名為溶質(zhì)載體家族5成員5,也被稱為NIS(鈉/碘轉(zhuǎn)運(yùn)蛋白)和TDH1(甲狀腺激素生成障礙1)。該蛋白主要在甲狀腺和哺乳期乳腺組織中吸收碘,對甲狀腺激素的生成至關(guān)重要。SLC5A5的突變與甲狀腺激素生成障礙1有關(guān),可能導(dǎo)致甲狀腺功能減退癥。此外,SLC5A5還與甲狀腺腫大、 Pendred綜合征等疾病相關(guān)。在藥物研發(fā)方面,針對SLC5A5的藥物主要針對甲狀腺相關(guān)疾病的治療,目前尚處于研發(fā)階段。

熱銷產(chǎn)品

Recombinant Human Sodium/iodide cotransporter (SLC5A5), partial (CSB-EP835713HU)

驗(yàn)證數(shù)據(jù)

CSB-EP835713HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SLC5A5 Antibody (CSB-PA835713LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA835713LA01HU

Western Blot
Positive WB detected in: Rat stomach tissue
All lanes: SLC5A5 antibody at 3.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 69 kDa
Observed band size: 69 kDa

CSB-PA835713LA01HU

IHC image of CSB-PA835713LA01HU diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA835713LA01HU

IHC image of CSB-PA835713LA01HU diluted at 1:500 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA835713LA01HU

Immunofluorescence staining of MCF-7 cells with CSB-PA835713LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SLC5A5 Antibodies

SLC5A5 for Homo sapiens (Human)

SLC5A5 Proteins

SLC5A5 Proteins for Rattus norvegicus (Rat)

SLC5A5 Proteins for Homo sapiens (Human)

SLC5A5 Proteins for Mus musculus (Mouse)