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SLC6A19

SLC6A19,即溶質(zhì)載體家族6成員19,別名HND、B0AT1。它是一種在人類腸道和腎臟上皮細胞中表達的跨膜蛋白,負責(zé)將中性氨基酸從細胞外轉(zhuǎn)運到細胞內(nèi)。SLC6A19的作用機制是通過主動轉(zhuǎn)運,將氨基酸從腸道吸收并在腎臟中重吸收。該基因的突變可能導(dǎo)致Hartnup病,這是一種遺傳性疾病,表現(xiàn)為糙皮病、小腦性共濟失調(diào)和精神病等癥狀。SLC6A19在氨基酸穩(wěn)態(tài)、糖尿病和體重控制中也扮演著重要角色。在腸道細胞中的表達和功能依賴于輔助蛋白血管緊張素轉(zhuǎn)換酶2(ACE2)的存在,ACE2也是SARS-CoV-2的細胞受體之一。

熱銷產(chǎn)品

SLC6A19 Antibody (CSB-PA731656LA01HU)

驗證數(shù)據(jù)

CSB-PA731656LA01HU

IHC image of CSB-PA731656LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA731656LA01HU

IHC image of CSB-PA731656LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA731656LA01HU

Immunofluorescence staining of Hela cells with CSB-PA731656LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SLC6A19 Antibodies

SLC6A19 for Homo sapiens (Human)

SLC6A19 Proteins

SLC6A19 Proteins for Homo sapiens (Human)