SLC6A4
SLC6A4，即鈉依賴性神經(jīng)遞質(zhì)轉(zhuǎn)運(yùn)蛋白，別名5-羥色胺轉(zhuǎn)運(yùn)體（5-HTT）、SERT等。SLC6A4是一種負(fù)責(zé)大腦中5-羥色胺（血清素）再攝取的跨膜蛋白，由人體細(xì)胞自身的基因編碼。它的作用機(jī)制主要是通過鈉離子和氯離子的共運(yùn)輸，將5-羥色胺從突觸間隙中移回神經(jīng)元，終止其信號(hào)傳導(dǎo)作用，從而調(diào)節(jié)情緒、睡眠、食欲等生理過程。SLC6A4的信號(hào)通路涉及到5-羥色胺能神經(jīng)系統(tǒng)，其活性受到多種因素的調(diào)控，包括細(xì)胞內(nèi)外的離子濃度、神經(jīng)遞質(zhì)濃度以及藥物作用等。SLC6A4在生物學(xué)上的意義非常廣泛，它不僅參與了情緒調(diào)節(jié)和認(rèn)知功能，還與多種精神疾病的發(fā)生發(fā)展密切相關(guān)，如抑郁癥、焦慮癥、強(qiáng)迫癥等。SLC6A4基因的多態(tài)性與個(gè)體對(duì)抑郁情緒的易感性有關(guān)，且抗抑郁藥物的作用機(jī)制之一就是通過增加突觸間隙中的5-羥色胺濃度來實(shí)現(xiàn)。此外，SLC6A4的功能異常還可能與某些神經(jīng)退行性疾病相關(guān)。因此，SLC6A4是精神藥理學(xué)研究和精神疾病治療中的一個(gè)重要靶點(diǎn)。
熱銷產(chǎn)品
SLC6A4 Recombinant Monoclonal Antibody (CSB-RA224413A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: U-87 whole cell lysate, 293T whole cell lysate, U-251 whole cell lysate, HepG2 whole cell lysate
All lanes: Serotonin transporter antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 71, 75 kDa
Observed band size: 55 kDa
IHC image of CSB-RA224413A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
SLC6A4 Antibodies
SLC6A4 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA550133 | SLC6A4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA363564 | SLC6A4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA224413A0HU | SLC6A4 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
SLC6A4 Proteins
SLC6A4 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP021702HU CSB-EP021702HU CSB-BP021702HU CSB-MP021702HU CSB-EP021702HU-B |
Recombinant Human Sodium-dependent serotonin transporter (SLC6A4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
