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SMAD3

SMAD3,也被稱為madh3或Smad家族成員3,是一種參與細(xì)胞信號傳導(dǎo)的轉(zhuǎn)錄因子。SMAD3蛋白參與多種過程,如水解酶活性的正向調(diào)節(jié)、基因表達(dá)調(diào)節(jié)以及跨膜受體蛋白絲氨酸/蘇氨酸激酶信號通路。SMAD3蛋白在多種疾病中發(fā)揮重要作用,包括炎癥性腸病、自身免疫性疾病以及腫瘤。在炎癥性腸病中,SMAD3信號通路缺陷會導(dǎo)致腸道炎癥和潰瘍。在自身免疫性疾病中,SMAD3蛋白的激活受損會影響免疫細(xì)胞亞型的平衡,導(dǎo)致自身免疫反應(yīng)。針對SMAD3蛋白的藥物研發(fā)主要集中在抑制其活性或阻斷其信號通路。一些小分子抑制劑已被開發(fā)用于治療炎癥性腸病和腫瘤。例如,E-SIS3是一種選擇性的SMAD3抑制劑,可以抑制成纖維細(xì)胞向肌成纖維細(xì)胞分化,從而減輕組織纖維化。此外,一些靶向SMAD3蛋白的抗體藥物也正在臨床研究中,用于治療多種疾病。

熱銷產(chǎn)品

Recombinant Human Mothers against decapentaplegic homolog 3 (SMAD3) (CSB-EP021788HUb0)

驗證數(shù)據(jù)

CSB-EP021788HUb0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SMAD3 Antibody (CSB-PA021788ESR2HU)

驗證數(shù)據(jù)

CSB-PA021788ESR2HU

Western blot
All lanes: SMAD3 antibody at 8μg/ml
Lane 1: Jurkat whole cell lysate
Lane 2: A431 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49, 44, 36, 26 kDa
Observed band size: 49 kDa

CSB-PA021788ESR2HU

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA021788ESR2HU at dilution of 1:100

CSB-PA021788ESR2HU

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA021788ESR2HU at dilution of 1:100

CSB-PA021788ESR2HU

Immunoprecipitating SMAD3 in Jurkat whole cell lysate
Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA021788ESR2HU in Jurkat whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA021788ESR2HU (4μg) + Jurkat whole cell lysate (500μg)
Lane 3: Jurkat whole cell lysate (20μg)

CSB-PA021788ESR2HU

IHC image of CSB-PA021788ESR2HU diluted at 1:388 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA021788ESR2HU

Immunofluorescence staining of A549 cells with CSB-PA021788ESR2HU at 1:129, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SMAD3 Antibodies

SMAD3 for Homo sapiens (Human)

SMAD3 Proteins

SMAD3 Proteins for Homo sapiens (Human)

SMAD3 Proteins for Rattus norvegicus (Rat)

SMAD3 Proteins for Gallus gallus (Chicken)

SMAD3 Proteins for Sus scrofa (Pig)

SMAD3 Proteins for Mus musculus (Mouse)