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SMARCD2

SMARCD2,即SWI/SNF相關(guān)矩陣相關(guān)蛋白D2,別名INI1、hSNF2α、BAF47等。它是一種由SMARCD2基因編碼的核蛋白,屬于SWI/SNF染色質(zhì)重塑復(fù)合體家族成員。SMARCD2的作用機(jī)制涉及其ATP酶活性,通過改變?nèi)旧|(zhì)結(jié)構(gòu),促進(jìn)轉(zhuǎn)錄因子的DNA結(jié)合,影響基因表達(dá)。SMARCD2在細(xì)胞增殖、分化、腫瘤抑制等多種生物學(xué)過程中發(fā)揮作用。SMARCD2的功能異常與多種疾病有關(guān),尤其是在癌癥中,如成神經(jīng)管細(xì)胞瘤、成視網(wǎng)膜細(xì)胞瘤等,SMARCD2的突變或缺失與腫瘤的發(fā)生發(fā)展密切相關(guān)。

熱銷產(chǎn)品

SMARCD2 Antibody (CSB-PA846114LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA846114LA01HU

Western Blot
Positive WB detected in: Raw264.7 whole cell lysate
All lanes: SMARCD2 antibody at 4.9μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 59, 58, 56 kDa
Observed band size: 59 kDa

CSB-PA846114LA01HU

IHC image of CSB-PA846114LA01HU diluted at 1:500 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

SMARCD2 Antibodies

SMARCD2 for Homo sapiens (Human)

SMARCD2 Proteins

SMARCD2 Proteins for Homo sapiens (Human)