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SMURF1

SMURF1,即Smad特異性E3泛素蛋白連接酶1,也稱為hSMURF1、KIAA1625。SMURF1是一種HECT型E3泛素連接酶,主要在人體細(xì)胞中表達(dá),尤其是在胚胎發(fā)育過程中的外胚層組織中高度表達(dá)。它的作用機(jī)制是通過與BMP(骨形態(tài)發(fā)生蛋白)通路中的Smad效應(yīng)子相互作用,導(dǎo)致Smad蛋白泛素化和降解,從而在調(diào)節(jié)細(xì)胞運(yùn)動(dòng)、細(xì)胞信號(hào)傳導(dǎo)和細(xì)胞極性方面起關(guān)鍵作用。SMURF1在細(xì)胞分化、組織形成和腫瘤發(fā)生等過程中具有重要的意義。SMURF1在體內(nèi)負(fù)調(diào)控成骨細(xì)胞分化和骨形成,并且與多種疾病相關(guān),包括神經(jīng)管閉合缺陷、Brachydactyly Type A2、Fanconi貧血等。

熱銷產(chǎn)品

Recombinant Human E3 ubiquitin-protein ligase SMURF1 (SMURF1), partial (CSB-EP875720HU1a0)

驗(yàn)證數(shù)據(jù)

CSB-EP875720HU1a0

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SMURF1 Antibody (CSB-PA875720LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA875720LA01HU

Western Blot
Positive WB detected in: U251 whole cell lysate, A549 whole cell lysate
All lanes: SMURF1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 87, 84 KDa
Observed band size: 87 KDa
Exposure time:5min

CSB-PA875720LA01HU

Immunofluorescence staining of A549 cells with CSB-PA875720LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

SMURF1 Antibodies

SMURF1 for Homo sapiens (Human)

SMURF1 Proteins

SMURF1 Proteins for Mus musculus (Mouse)

SMURF1 Proteins for Homo sapiens (Human)

SMURF1 Proteins for Xenopus laevis (African clawed frog)

SMURF1 ELISA Kit

SMURF1 ELISA Kit for Mus musculus (Mouse)