SPP1

SPP1蛋白全稱分泌磷蛋白1，又稱骨橋蛋白或OPN，是一種多功能糖蛋白，廣泛存在于骨骼、免疫細(xì)胞及腫瘤微環(huán)境中。SPP1通過與整合素受體結(jié)合，參與調(diào)控細(xì)胞黏附、遷移及礦化過程，在骨折修復(fù)和血管鈣化中具有雙重調(diào)節(jié)作用。SPP1異常高表達(dá)與乳腺癌、肝癌等實體瘤轉(zhuǎn)移密切相關(guān)，同時與多發(fā)性硬化癥、動脈粥樣硬化等慢性炎癥性疾病進(jìn)程存在顯著關(guān)聯(lián)。在骨質(zhì)疏松患者中，血清SPP1水平可作為骨質(zhì)流失的動態(tài)監(jiān)測指標(biāo)。
針對SPP1的治療策略主要采用單克隆抗體中和其病理功能。人源化抗體KPL-404在類風(fēng)濕性關(guān)節(jié)炎Ⅱ期試驗中表現(xiàn)出抑制關(guān)節(jié)破壞的潛力，而siRNA藥物STP705通過局部注射降低瘢痕疙瘩中SPP1表達(dá)量，已完成皮膚纖維化治療的Ⅰ期安全性驗證。某些天然多酚化合物被發(fā)現(xiàn)能阻斷SPP1與CD44受體的相互作用，這為開發(fā)口服小分子抑制劑提供了新方向，但其生物利用度仍是當(dāng)前研究瓶頸。

熱銷產(chǎn)品

Recombinant Human Osteopontin (SPP1) (CSB-MP022603HU(F5))

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SPP1 Recombinant Monoclonal Antibody (CSB-RA022603MA1HU)

驗證數(shù)據(jù)

Overlay Peak curve showing A549 cells stained with CSB-RA022603MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*10⁶cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*10⁶cells) used under the same conditions. Acquisition of >10, 000 events was performed.

SPP1 Antibody

SPP1 Protein

SPP1 ELISA Kit

SPP1 Antibodies

SPP1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA06904A0Rb	SPP1 Antibody	Human	ELISA, IHC
CSB-PA06904C0Rb	SPP1 Antibody, FITC conjugated	Human
CSB-PA06904D0Rb	SPP1 Antibody, Biotin conjugated	Human	ELISA
CSB-PA06904B0Rb	SPP1 Antibody, HRP conjugated	Human	ELISA
CSB-PA827743	SPP1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA003599	SPP1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA297038	SPP1 Antibody	Human	ELISA,WB,IHC
CSB-PA264573	SPP1 Antibody	Human,Mouse	ELISA,WB
CSB-RA261140A0HU	SPP1 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC
CSB-RA022603MA1HU	SPP1 Recombinant Monoclonal Antibody	Human	ELISA, FC

SPP1 for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA022603YD01MO	Spp1 Antibody, Biotin conjugated	Mouse	ELISA
CSB-PA022603YA01MO	Spp1 Antibody	Mouse	ELISA, WB

SPP1 Proteins

SPP1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP022603HU(F5)	Recombinant Human Osteopontin (SPP1)	Yeast
CSB-YP021198HU CSB-EP021198HU CSB-BP021198HU CSB-MP021198HU CSB-EP021198HU-B	Recombinant Human Sphingosine-1-phosphate phosphatase 1 (SGPP1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-MP022603HU(F5)	Recombinant Human Osteopontin (SPP1)	Mammalian cell

SPP1 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP022603MO	Recombinant Mouse Osteopontin (Spp1), partial	Yeast
CSB-BP022603MO CSB-MP022603MO CSB-EP022603MO-B	Recombinant Mouse Osteopontin (Spp1), partial	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP022603PI CSB-EP022603PI CSB-BP022603PI CSB-MP022603PI CSB-EP022603PI-B	Recombinant Pig Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP022603BO CSB-EP022603BO CSB-BP022603BO CSB-MP022603BO CSB-EP022603BO-B	Recombinant Bovine Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Gallus gallus (Chicken)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP022603CH CSB-EP022603CH CSB-BP022603CH CSB-MP022603CH CSB-EP022603CH-B	Recombinant Chicken Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP022603RB CSB-EP022603RB CSB-BP022603RB CSB-MP022603RB CSB-EP022603RB-B	Recombinant Rabbit Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP022603RA CSB-EP022603RA CSB-BP022603RA CSB-MP022603RA CSB-EP022603RA-B	Recombinant Rat Osteopontin (Spp1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP527933SXV CSB-EP527933SXV CSB-BP527933SXV CSB-MP527933SXV CSB-EP527933SXV-B	Recombinant Schizosaccharomyces pombe Set1 complex component spp1 (spp1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Nicotiana tabacum (Common tobacco)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP708413NHE CSB-EP708413NHE CSB-BP708413NHE CSB-MP708413NHE CSB-EP708413NHE-B	Recombinant Nicotiana tabacum Sucrose-phosphatase 1 (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Oryza sativa subsp. japonica (Rice)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP842478OFG CSB-EP842478OFG CSB-BP842478OFG CSB-MP842478OFG CSB-EP842478OFG-B	Recombinant Oryza sativa subsp. japonica Probable sucrose-phosphatase 1 (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP863231DOA CSB-EP863231DOA CSB-BP863231DOA CSB-MP863231DOA CSB-EP863231DOA-B	Recombinant Arabidopsis thaliana Probable sucrose-phosphatase 1 (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Zea mays (Maize)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP884318ZAX CSB-EP884318ZAX CSB-BP884318ZAX CSB-MP884318ZAX CSB-EP884318ZAX-B	Recombinant Zea mays Sucrose-phosphatase 1 (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SPP1 Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP893170SH CSB-EP893170SH CSB-BP893170SH CSB-MP893170SH CSB-EP893170SH-B	Recombinant Sheep Osteopontin (SPP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli