SRC
SRC,即肉瘤病毒蛋白Src,別名c-Src、p60-Src等。它是一種非受體酪氨酸激酶,屬于Src家族蛋白酪氨酸激酶成員,由人體細(xì)胞自身的SRC基因編碼。SRC在多種細(xì)胞類型中都有表達(dá),尤其在淋巴細(xì)胞和成骨細(xì)胞中表達(dá)較高。SRC的作用機(jī)制主要通過其激酶活性參與調(diào)節(jié)細(xì)胞內(nèi)的信號傳導(dǎo),它能夠磷酸化多種蛋白質(zhì)的酪氨酸殘基,從而激活或抑制這些蛋白質(zhì)的功能。SRC的活性受到多種因素的調(diào)控,包括磷酸化、去磷酸化、寡聚化和與膜的結(jié)合等。SRC在生物學(xué)上的意義非常廣泛,它參與了細(xì)胞的多種生理過程,包括細(xì)胞增殖、分化、遷移、黏附和凋亡等。SRC通過激活下游的多種信號通路,如MAPK、PI3K/AKT、JAK/STAT等,對細(xì)胞的生存和功能發(fā)揮重要作用。此外,SRC的功能異常與多種疾病的發(fā)生發(fā)展有關(guān),尤其是與腫瘤的發(fā)生、發(fā)展和轉(zhuǎn)移密切相關(guān)。在腫瘤細(xì)胞中,SRC的過度活化可以促進(jìn)腫瘤細(xì)胞的增殖和侵襲,使其成為腫瘤治療中的一個潛在靶點。因此,針對SRC的小分子抑制劑正在被開發(fā)用于治療某些類型的癌癥。
熱銷產(chǎn)品
Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC) (CSB-EP022650HU)
驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
SRC Recombinant Monoclonal Antibody (CSB-RA022650A0HU)
驗證數(shù)據(jù)

Western Blot
Positive WB detected in: NIH/3T3 whole cell lysate, MCF-7 whole cell lysate
All lanes: SRC antibody at 1.2μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 60, 61 KDa
Observed band size: 60, 61 KDa

Immunofluorescence staining of MCF-7 cells with CSB-RA022650A0HU at 1:39, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

Overlay histogram showing SH-SY5Y cells stained with CSB-RA022650A0HU (red line) at 1:50. The cells were fixed with 70% Ethylalcohol (18h) and then permeabilized with 0.3% Triton X-100 for 2 min. The cells were then incubated in 1x PBS /10% normal goat serum to block non-specific protein-protein interactions followed by primary antibody for 1 h at 4℃. The secondary antibody used was FITC goat anti-rabbit IgG (H+L) at 1/200 dilution for 1 h at 4℃. Control antibody (green line) was used under the same conditions. Acquisition of >10,000 events was performed.
Human Proto-oncogene tyrosine-protein kinase Src(SRC) ELISA kit (CSB-EL022650HU)
驗證數(shù)據(jù)

貨號:CSB-EL022650HU
規(guī)格:96T/48T
靈敏度:6.25 pg/mL
檢測范圍:25 pg/mL-1600 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
SRC Antibodies
SRC for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA022650GA01HU | SRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IP,IF |
CSB-PA954497 | Phospho-SRC (Tyr529) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA829908 | SRC (Ab-529) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA014991 | Phospho-SRC (Tyr418) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA928286 | Phospho-SRC (Ser75) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA000506 | Phospho-SRC (Y529) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
CSB-PA000637 | Phospho-SRC (Y419) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA001803 | SRC Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA001806 | SRC Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA001807 | SRC Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA001809 | SRC Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA050132 | Phospho-SRC (Y216) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA050133 | Phospho-SRC (S75) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA050134 | SRC Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA081645 | SRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA080378 | SRC Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-RA022650A0HU | SRC Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IF, FC |
CSB-PA022650LA01HU | SRC Antibody | Human | ELISA, WB, IHC |
CSB-PA022650LB01HU | SRC Antibody, HRP conjugated | Human | ELISA |
CSB-PA022650LC01HU | SRC Antibody, FITC conjugated | Human | |
CSB-PA022650LD01HU | SRC Antibody, Biotin conjugated | Human | ELISA |
CSB-PA022650LA11HU | SRC Antibody | Human | ELISA, IHC |
CSB-PA022650LB11HU | SRC Antibody, HRP conjugated | Human | ELISA |
CSB-PA022650LC11HU | SRC Antibody, FITC conjugated | Human | |
CSB-PA022650LD11HU | SRC Antibody, Biotin conjugated | Human | ELISA |
SRC for Danio rerio (Zebrafish) (Brachydanio rerio)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA24479A0Rb | src Antibody | Zebrafish | ELISA, WB |
CSB-PA24479B0Rb | src Antibody, HRP conjugated | Zebrafish | ELISA |
CSB-PA24479C0Rb | src Antibody, FITC conjugated | Zebrafish | |
CSB-PA24479D0Rb | src Antibody, Biotin conjugated | Zebrafish | ELISA |
SRC Proteins
SRC Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP022650HU CSB-BP022650HU CSB-MP022650HU CSB-EP022650HU-B |
Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP022650HU | Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC) | E.coli |
CSB-EP022650HUe1 | Recombinant Human Proto-oncogene tyrosine-protein kinase Src (SRC) | E.coli |
SRC Proteins for Mus musculus (Mouse)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP022650MO CSB-EP022650MO CSB-BP022650MO CSB-MP022650MO CSB-EP022650MO-B |
Recombinant Mouse Neuronal proto-oncogene tyrosine-protein kinase Src (Src) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SRC Proteins for Gallus gallus (Chicken)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP022650CH CSB-EP022650CH CSB-BP022650CH CSB-MP022650CH CSB-EP022650CH-B |
Recombinant Chicken Proto-oncogene tyrosine-protein kinase Src (SRC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SRC Proteins for Rattus norvegicus (Rat)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP894363RA CSB-EP894363RA CSB-BP894363RA CSB-MP894363RA CSB-EP894363RA-B |
Recombinant Rat Proto-oncogene tyrosine-protein kinase Src (Src) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SRC ELISA Kit
SRC ELISA Kit for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
---|---|---|---|
CSB-EL022650HU | Human Proto-oncogene tyrosine-protein kinase Src(SRC) ELISA kit | serum, plasma, tissue homogenates, cell lysates | 6.25 pg/mL |