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STAT1

STAT1,即信號轉(zhuǎn)導(dǎo)與轉(zhuǎn)錄激活因子1,別名包括CANDF7、IMD31A、IMD31B、IMD31C、ISGF-3、STAT91等。該基因位于2號染色體上,編碼的蛋白質(zhì)是STAT蛋白家族的成員。STAT1在細(xì)胞因子和生長因子的作用下,通過受體相關(guān)激酶磷酸化后形成同源或異源二聚體,并轉(zhuǎn)運(yùn)到細(xì)胞核內(nèi),作為轉(zhuǎn)錄激活因子調(diào)控靶基因的表達(dá)。STAT1干擾素信號通路,參與調(diào)控免疫應(yīng)答、細(xì)胞增殖、凋亡和分化等多種生物學(xué)過程。STAT1對于維持機(jī)體穩(wěn)態(tài)和抵御病原體感染具有重要作用,同時也在腫瘤抑制中扮演關(guān)鍵角色,如通過促進(jìn)細(xì)胞凋亡、抑制細(xì)胞增殖等方式抑制膠質(zhì)瘤等惡性腫瘤的發(fā)展。

熱銷產(chǎn)品

STAT1 Recombinant Monoclonal Antibody (CSB-RA989713A0HU)

驗證數(shù)據(jù)

CSB-RA989713A0HU

IHC image of CSB-RA989713A0HU diluted at 1:50 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.40% DAB.

CSB-RA989713A0HU

Immunofluorescence staining of Hela with CSB-RA989713A0HU at 1:25, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 508-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

CSB-RA989713A0HU

Overlay Peak curve showing HepG2 cells stained with CSB-RA989713A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

STAT1 Antibodies

STAT1 for Homo sapiens (Human)

STAT1 Proteins

STAT1 Proteins for Mus musculus (Mouse)

STAT1 Proteins for Homo sapiens (Human)

STAT1 Proteins for Sus scrofa (Pig)