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TBK1

TBK1,即TANK結(jié)合激酶1,別名T2K、NAK等。TBK1是一種絲氨酸/蘇氨酸蛋白激酶,屬于非經(jīng)典的IKK激酶家族。TBK1的作用機(jī)制涉及其激酶活性,特別是激酶結(jié)構(gòu)域中的Ser172位點(diǎn)的磷酸化,這是TBK1激酶活性的關(guān)鍵調(diào)節(jié)位點(diǎn)。TBK1在固有免疫系統(tǒng)中扮演著關(guān)鍵角色,能夠激活NF-κB轉(zhuǎn)錄因子和干擾素調(diào)節(jié)因子(IRFs),對(duì)抵抗病原微生物的入侵和產(chǎn)生炎性細(xì)胞因子至關(guān)重要。TBK1的活性異常與多種疾病相關(guān),包括炎癥性疾病、自身免疫疾病、癌癥和神經(jīng)退行性疾病,是藥物發(fā)現(xiàn)的新興治療靶點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human Serine/threonine-protein kinase TBK1 (TBK1), partial (CSB-EP890690HU1)

驗(yàn)證數(shù)據(jù)

CSB-EP890690HU1

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TBK1 Recombinant Monoclonal Antibody (CSB-RA932866A0HU)

驗(yàn)證數(shù)據(jù)

CSB-RA932866A0HU

IHC image of CSB-RA932866A0HU diluted at 1:100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA932866A0HU

IHC image of CSB-RA932866A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

CSB-RA932866A0HU

Overlay Peak curve showing A549 cells stained with CSB-RA932866A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.

TBK1 Antibodies

TBK1 for Homo sapiens (Human)

TBK1 Proteins

TBK1 Proteins for Xenopus laevis (African clawed frog)

TBK1 Proteins for Homo sapiens (Human)

TBK1 Proteins for Mus musculus (Mouse)