TET2
TET2，甲基胞嘧啶雙加氧酶2，別名Ten-eleventranslocation2(TET-2)。它是一種α-酮戊二酸和Fe2+依賴的雙加氧酶，主要來(lái)源于哺乳動(dòng)物的TET蛋白家族，該家族包括TET1、TET2和TET3三個(gè)成員。TET2的作用機(jī)制是通過(guò)催化5-甲基胞嘧啶(5mC)氧化生成5-羥甲基胞嘧啶(5hmC)，進(jìn)而通過(guò)一系列的氧化步驟最終轉(zhuǎn)化為未修飾的胞嘧啶，這一過(guò)程是DNA主動(dòng)去甲基化的重要途徑。TET2在細(xì)胞命運(yùn)決定、分化、腫瘤發(fā)生發(fā)展以及免疫調(diào)控中發(fā)揮重要作用。TET2的異常表達(dá)或突變與多種疾病相關(guān)，包括髓系腫瘤和免疫相關(guān)疾病。在腫瘤抑制方面，TET2通過(guò)調(diào)控基因表達(dá)和DNA甲基化狀態(tài)，影響細(xì)胞增殖和分化。在免疫調(diào)控中，TET2能夠影響炎癥因子的分泌，參與炎癥反應(yīng)的調(diào)控。
熱銷產(chǎn)品
TET2 Antibody (CSB-PA764560ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA764560ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA764560ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA764560ESR1HU at dilution of 1:100
TET2 Antibodies
TET2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023397GA01HU | TET2 Antibody | Human | ELISA,WB |
| CSB-PA764560ESR1HU | TET2 Antibody | Human | ELISA, IHC |
TET2 Proteins
TET2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP678395MO CSB-BP678395MO CSB-MP678395MO CSB-EP678395MO-B |
Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP678395MO | Recombinant Mouse Methylcytosine dioxygenase TET2 (Tet2), partial | E.coli |
TET2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP764560HU CSB-EP764560HU CSB-BP764560HU CSB-MP764560HU CSB-EP764560HU-B |
Recombinant Human Methylcytosine dioxygenase TET2 (TET2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
