TGM2
組織型谷氨酰胺轉(zhuǎn)移酶2（TGM2）也被稱為TG2或組織轉(zhuǎn)谷氨酰胺酶，是一種多功能酶類蛋白。它廣泛分布于人體組織，通過催化蛋白質(zhì)交聯(lián)參與細(xì)胞結(jié)構(gòu)維持、損傷修復(fù)等生理過程，其活性受鈣離子濃度調(diào)控。該蛋白在細(xì)胞應(yīng)激狀態(tài)下被激活，既能穩(wěn)定胞外基質(zhì)，也可進(jìn)入細(xì)胞核影響基因表達(dá)，同時(shí)與炎癥因子釋放、免疫調(diào)節(jié)密切相關(guān)。TGM2的異常表達(dá)與器官纖維化進(jìn)程、神經(jīng)退行性疾?。ㄈ绨柎暮Ｄ。┮约岸喾N惡性腫瘤的侵襲轉(zhuǎn)移存在關(guān)聯(lián)。
在疾病干預(yù)領(lǐng)域，TGM2已成為纖維化疾病和特定癌癥的治療靶點(diǎn)。針對(duì)其開發(fā)的不可逆抑制劑如胱胺衍生物已進(jìn)入臨床前研究，部分小分子化合物在動(dòng)物模型中顯示出延緩肺纖維化進(jìn)展的效果。該蛋白在腫瘤微環(huán)境中呈現(xiàn)雙重作用：既能促進(jìn)癌細(xì)胞的耐藥性，又可抑制部分免疫細(xì)胞的抗腫瘤活性，這種復(fù)雜性為藥物研發(fā)帶來挑戰(zhàn)。當(dāng)前研究正致力于開發(fā)具有組織選擇性的調(diào)控劑，以期在疾病治療中實(shí)現(xiàn)更精準(zhǔn)的干預(yù)。
熱銷產(chǎn)品
Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial (CSB-EP023462HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TGM2 Recombinant Monoclonal Antibody (CSB-RA147681A0HU)
驗(yàn)證數(shù)據(jù)
Western Blot
Positive WB detected in: U87 whole cell lysate
All lanes: TGM2 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 78, 62, 39 kDa
Observed band size: 78 kDa
Human transglutaminase 2C polypeptide,TGM2 ELISA Kit (CSB-E11797h)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E11797h
規(guī)格：96T/48T
靈敏度：4.68 pg/mL
檢測范圍：18.75 pg/mL-1200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TGM2 Antibodies
TGM2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA11809A0Rb | TGM2 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA023462GA01HU | TGM2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-MA0234621A0m | TGM2 Monoclonal Antibody | Human | ELISA,WB,IHC |
| CSB-PA032600 | TGM2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA023462ESR1HU | TGM2 Antibody | Human | ELISA, IHC |
| CSB-PA023462ESR2HU | TGM2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA004272 | TGM2 Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA596121 | TGM2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA546098 | TGM2 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA147681A0HU | TGM2 Recombinant Monoclonal Antibody | Human | ELISA, WB |
TGM2 Proteins
TGM2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023462HU CSB-BP023462HU CSB-MP023462HU CSB-EP023462HU-B |
Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP023462HU | Recombinant Human Protein-glutamine gamma-glutamyltransferase 2 (TGM2), partial | E.coli |
TGM2 ELISA Kit
TGM2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11797h | Human transglutaminase 2C polypeptide,TGM2 ELISA Kit | serum, plasma, tissue homogenates | 4.68 pg/mL |
