THRB
THRB，即甲狀腺激素受體β，別名C-ErbA-Beta2、NR1A2、THRbeta1等。它是一種核受體，由THRB基因編碼，對三碘甲狀腺原氨酸（T3）具有高親和力。THRB的作用機制主要是通過與T3結(jié)合后，調(diào)控靶基因的轉(zhuǎn)錄，可以作為轉(zhuǎn)錄激活因子或抑制因子。THRB能夠結(jié)合到基因組上的特定DNA序列上，調(diào)節(jié)多種生理過程，包括代謝、生長和發(fā)育。THRB在生物學(xué)上的意義非常廣泛，它參與調(diào)節(jié)的信號通路涉及細(xì)胞的增殖、分化、能量代謝、神經(jīng)系統(tǒng)發(fā)育等。THRB的功能異常與多種疾病有關(guān)，例如普遍性甲狀腺激素抵抗癥（Generalized Thyroid Hormone Resistance, GTHR），這是一種以甲狀腺腫大和循環(huán)甲狀腺激素（T3-T4）水平升高為特征的疾病，同時伴有正?；蚵愿叩募谞钕俅碳ぜに兀═SH）水平。此外，THRB的表達(dá)和活性還與肝臟的脂質(zhì)代謝有關(guān)，研究發(fā)現(xiàn)，在THRB缺陷的小鼠中，肝臟的晝夜代謝節(jié)律發(fā)生顯著變化，導(dǎo)致膽固醇、三酰甘油和二酰甘油以及脂肪酸水平升高，進而可能促進脂肪肝的發(fā)展。
熱銷產(chǎn)品
Recombinant Human Thyroid hormone receptor beta (THRB) (CSB-EP023514HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP023514HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) THRB.
THRB Antibody (CSB-PA023514LA01HU)
驗證數(shù)據(jù)
Western blot
All lanes: THRB antibody at 2µg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 53, 55 kDa
Observed band size: 53 kDa
Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA023514LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA023514LA01HU at dilution of 1:100
THRB Antibodies
THRB for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA050260 | Phospho-THRB (S142) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA050261 | THRB Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA023514LA01HU | THRB Antibody | Human, Mouse | ELISA, WB, IHC |
THRB Proteins
THRB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023514HU CSB-BP023514HU CSB-MP023514HU CSB-EP023514HU-B |
Recombinant Human Thyroid hormone receptor beta (THRB) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP023514HU | Recombinant Human Thyroid hormone receptor beta (THRB) | E.coli |
