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TIPARP

TIPARP,即TCDD誘導(dǎo)型聚(ADP-核糖)聚合酶,別名PARP7、ARTD14、pART14。TIPARP由人類TIPARP基因編碼,該基因位于3號(hào)染色體的q25.31區(qū)域。TIPARP是一種聚(ADP-核糖)聚合酶超家族的成員,它使用NAD+作為底物,將ADP-核糖轉(zhuǎn)移到蛋白質(zhì)受體的谷氨酸殘基上;反復(fù)的ADP-核糖基化作用導(dǎo)致在蛋白質(zhì)上形成聚鏈,從而改變目標(biāo)蛋白的功能。TIPARP在多種生理過程中發(fā)揮作用,包括基因調(diào)控、病毒響應(yīng)和細(xì)胞骨架調(diào)控。TIPARP的異常調(diào)控可能引起神經(jīng)發(fā)育障礙、異常的抗病毒反應(yīng)、某些類型的癌癥以及二惡英誘導(dǎo)的肝脂肪變性。

熱銷產(chǎn)品

Recombinant Human Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) (CSB-BP801800HU)

驗(yàn)證數(shù)據(jù)

CSB-BP801800HU

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TIPARP Antibody (CSB-PA801800LA01HU)

驗(yàn)證數(shù)據(jù)

CSB-PA801800LA01HU

Western Blot
Positive WB detected in: U87 whole cell lysate, SH-SY5Y whole cell lysate
All lanes: TIPARP antibody at 4.6µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 77 kDa
Observed band size: 77 kDa

CSB-PA801800LA01HU

IHC image of CSB-PA801800LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

CSB-PA801800LA01HU

IHC image of CSB-PA801800LA01HU diluted at 1:300 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

TIPARP Antibodies

TIPARP for Homo sapiens (Human)

TIPARP Proteins

TIPARP Proteins for Homo sapiens (Human)