TLR4

TLR4全名Toll樣受體4，也被稱為CD284或hToll，是機體感知病原體入侵的重要"哨兵"。TLR4主要駐扎在免疫細胞表面，能夠敏銳識別細菌脂多糖等危險信號，迅速激活防御系統(tǒng)。當它與特定分子結合時，會聯(lián)動細胞內多種信號分子，促使免疫細胞釋放炎性因子，同時協(xié)調吞噬細胞清除病原體。這種快速反應機制在對抗感染中不可或缺，但過度激活可能引發(fā)全身炎癥風暴。
TLR4功能失衡與多種疾病密切相關。在敗血癥和急性呼吸窘迫綜合征患者中，其異?；钴S會加劇組織損傷；而在某些腫瘤微環(huán)境和慢性感染中，其活性抑制又可能導致免疫應答不足。近年來針對該靶點的藥物研發(fā)聚焦于調控其活性窗口，例如TAK-242等抑制劑曾嘗試用于膿毒癥治療，新型納米抗體則探索在自身免疫病中的應用。部分研究團隊正嘗試將其調控劑與化療藥物聯(lián)用，以改善腫瘤免疫治療效果。

熱銷產品

Recombinant Human Toll-like receptor 4 (TLR4), partial (CSB-EP023603HU1)

驗證數據

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

TLR4 Recombinant Monoclonal Antibody (CSB-RA023603MA1HU)

驗證數據

Overlay Peak curve showing Hela cells stained with CSB-RA023603MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-human IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was human IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

Human toll-like receptor 4,TLR4 ELISA Kit (CSB-E12954h)

驗證數據

貨號：CSB-E12954h

規(guī)格：96T/48T

靈敏度：0.039 ng/mL

檢測范圍：0.156 ng/mL-10 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

TLR4 Antibody

TLR4 Protein

TLR4 ELISA Kit

TLR4 Antibodies

TLR4 for Homo sapiens (Human)

產品貨號	產品名稱	種屬反應性	應用類型
CSB-PA023603GA01HU	TLR4 Antibody	Human,Mouse,Rat,Bovin	ELISA,WB
CSB-PA001434	TLR4 Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA080181	TLR4 Antibody	Human,Mouse,Rat	IHC, ELISA
CSB-PA237733	TLR4 Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA902590	TLR4 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA776633	TLR4 Antibody	Human	ELISA,IHC
CSB-PA585936	TLR4 Antibody	Human	ELISA,IHC
CSB-RA023603MA1HU	TLR4 Recombinant Monoclonal Antibody	Human	ELISA, FC

TLR4 Proteins

TLR4 Proteins for Felis catus (Cat) (Felis silvestris catus)

產品貨號	產品名稱	來源
CSB-YP023603CA CSB-EP023603CA CSB-BP023603CA CSB-MP023603CA CSB-EP023603CA-B	Recombinant Cat Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Homo sapiens (Human)

產品貨號	產品名稱	來源
CSB-YP023603HU CSB-EP023603HU CSB-BP023603HU CSB-MP023603HU CSB-EP023603HU-B	Recombinant Human Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP023603HU1	Recombinant Human Toll-like receptor 4 (TLR4), partial	E.coli
CSB-BP023603HU1	Recombinant Human Toll-like receptor 4 (Tlr4), partial	Baculovirus

TLR4 Proteins for Sus scrofa (Pig)

產品貨號	產品名稱	來源
CSB-YP023603PI CSB-EP023603PI CSB-BP023603PI CSB-MP023603PI CSB-EP023603PI-B	Recombinant Pig Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

產品貨號	產品名稱	來源
CSB-YP023603GGZ CSB-EP023603GGZ CSB-BP023603GGZ CSB-MP023603GGZ CSB-EP023603GGZ-B	Recombinant Gorilla gorilla gorilla Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Pongo pygmaeus (Bornean orangutan)

產品貨號	產品名稱	來源
CSB-YP023603EXP CSB-EP023603EXP CSB-BP023603EXP CSB-MP023603EXP CSB-EP023603EXP-B	Recombinant Pongo pygmaeus Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Bos taurus (Bovine)

產品貨號	產品名稱	來源
CSB-YP023603BO CSB-EP023603BO CSB-BP023603BO CSB-MP023603BO CSB-EP023603BO-B	Recombinant Bovine Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Equus caballus (Horse)

產品貨號	產品名稱	來源
CSB-YP023603HO CSB-EP023603HO CSB-BP023603HO CSB-MP023603HO CSB-EP023603HO-B	Recombinant Horse Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Rattus norvegicus (Rat)

產品貨號	產品名稱	來源
CSB-YP023603RA CSB-EP023603RA CSB-BP023603RA CSB-MP023603RA CSB-EP023603RA-B	Recombinant Rat Toll-like receptor 4 (Tlr4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF023603RA	Recombinant Rat Toll-like receptor 4 (Tlr4), partial	in vitro E.coli expression system

TLR4 Proteins for Papio anubis (Olive baboon)

產品貨號	產品名稱	來源
CSB-YP023603ERI CSB-EP023603ERI CSB-BP023603ERI CSB-MP023603ERI CSB-EP023603ERI-B	Recombinant Papio anubis Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Mus musculus (Mouse)

產品貨號	產品名稱	來源
CSB-YP023603MO	Recombinant Mouse Toll-like receptor 4 (Tlr4), partial	Yeast
CSB-EP023603MO CSB-BP023603MO CSB-MP023603MO CSB-EP023603MO-B	Recombinant Mouse Toll-like receptor 4 (Tlr4), partial	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)

產品貨號	產品名稱	來源
CSB-YP023603EQU CSB-EP023603EQU CSB-BP023603EQU CSB-MP023603EQU CSB-EP023603EQU-B	Recombinant Pan paniscus Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

產品貨號	產品名稱	來源
CSB-YP023603DXU CSB-EP023603DXU CSB-BP023603DXU CSB-MP023603DXU CSB-EP023603DXU-B	Recombinant Cricetulus griseus Toll-like receptor 4 (TLR4), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TLR4 Proteins for Boselaphus tragocamelus (Nilgai)

產品貨號	產品名稱	來源
CSB-YP023603BUN CSB-EP023603BUN CSB-BP023603BUN CSB-MP023603BUN CSB-EP023603BUN-B	Recombinant Boselaphus tragocamelus Toll-like receptor 4 (TLR4)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli