TNFRSF10B
TNFRSF10B，即腫瘤壞死因子受體超家族成員10B，也稱為死亡受體5（DR5）。它是一種主要在多種組織中表達(dá)的細(xì)胞表面受體，尤其在腫瘤細(xì)胞中表達(dá)水平較高。TNFRSF10B的作用機(jī)制是通過(guò)與腫瘤壞死因子相關(guān)的凋亡誘導(dǎo)配體（TRAIL）結(jié)合，觸發(fā)細(xì)胞凋亡信號(hào)通路。其信號(hào)通路涉及TRAIL與TNFRSF10B結(jié)合后，死亡結(jié)構(gòu)域（DD）的聚集，進(jìn)而招募Fas相關(guān)死亡結(jié)構(gòu)域蛋白（FADD）和啟動(dòng)caspase級(jí)聯(lián)反應(yīng)，特別是激活caspase-8，導(dǎo)致細(xì)胞程序性死亡。TNFRSF10B在調(diào)控細(xì)胞生存與死亡平衡中扮演關(guān)鍵角色，其在腫瘤細(xì)胞凋亡中的特異性作用使其成為癌癥治療的有希望的靶點(diǎn)，有助于開(kāi)發(fā)新的靶向治療策略，以增強(qiáng)腫瘤細(xì)胞對(duì)凋亡的敏感性。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
TNFRSF10B Antibody (CSB-PA08165A0Rb)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of HepG2 cells with CSB-PA08165A0Rb at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
TNFRSF10B Antibodies
TNFRSF10B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023965GA01HU | TNFRSF10B Antibody | Human | ELISA,WB |
| CSB-PA018500 | TNFRSF10B Antibody | Human | ELISA,WB |
| CSB-PA08165A0Rb | TNFRSF10B Antibody | Human | ELISA, IF |
| CSB-PA08165B0Rb | TNFRSF10B Antibody, HRP conjugated | Human | ELISA |
| CSB-PA08165C0Rb | TNFRSF10B Antibody, FITC conjugated | Human | |
| CSB-PA08165D0Rb | TNFRSF10B Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA023965MA1HU | TNFRSF10B Recombinant Monoclonal Antibody | Human | ELISA, WB, IF |
TNFRSF10B Proteins
TNFRSF10B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP023965HU1 CSB-EP023965HU1 CSB-BP023965HU1 CSB-EP023965HU1-B |
Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-AP002291HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B),Partial (Active) | E.Coli |
| CSB-CF023965HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) | in vitro E.coli expression system |
| CSB-AP004921HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial (Active) | Mammalian cell |
| CSB-AP004931HU | Recombinant Human Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), partial (Active) | Mammalian cell |
TNFRSF10B Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP886404MO CSB-EP886404MO CSB-BP886404MO CSB-MP886404MO CSB-EP886404MO-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 10B (Tnfrsf10b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP005041MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 10B (Tnfrsf10b), partial (Active) | Mammalian cell |
TNFRSF10B ELISA Kit
TNFRSF10B ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13164h | Human Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2(TRAIL-R2/DR5) ELISA Kit | serum, plasma | 7.8 pg/mL |
