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TPX2

TPX2,即微管成核因子,別名DIL2、p100、HCTP4、FLS353、HCA519。TPX2是一種微管相關(guān)蛋白,參與微管的成核和組織。TPX2與Ran-GTP的相互作用以及與Aurora A激酶的結(jié)合在紡錘體的組裝和形成中發(fā)揮重要作用。TPX2在細(xì)胞周期運轉(zhuǎn)過程中起著關(guān)鍵作用,特別是在細(xì)胞有絲分裂時,TPX2通過結(jié)合蛋白激酶Aurora A,促進Aurora A的結(jié)構(gòu)變化,進而影響紡錘體的形成。TPX2的異常表達(dá)與多種腫瘤的發(fā)生發(fā)展相關(guān),包括膀胱癌和宮頸癌,其在腫瘤細(xì)胞中的過表達(dá)能促進腫瘤細(xì)胞的惡性增生及細(xì)胞轉(zhuǎn)移。

熱銷產(chǎn)品

TPX2 Antibody (CSB-PA892151LA01HU)

驗證數(shù)據(jù)

CSB-PA892151LA01HU

Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: TPX2 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 86, 90 kDa
Observed band size: 86 kDa

CSB-PA892151LA01HU

IHC image of CSB-PA892151LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

TPX2 Antibodies

TPX2 for Homo sapiens (Human)

TPX2 Proteins

TPX2 Proteins for Homo sapiens (Human)