TPX2
TPX2,即微管成核因子,別名DIL2、p100、HCTP4、FLS353、HCA519。TPX2是一種微管相關(guān)蛋白,參與微管的成核和組織。TPX2與Ran-GTP的相互作用以及與Aurora A激酶的結(jié)合在紡錘體的組裝和形成中發(fā)揮重要作用。TPX2在細(xì)胞周期運轉(zhuǎn)過程中起著關(guān)鍵作用,特別是在細(xì)胞有絲分裂時,TPX2通過結(jié)合蛋白激酶Aurora A,促進Aurora A的結(jié)構(gòu)變化,進而影響紡錘體的形成。TPX2的異常表達(dá)與多種腫瘤的發(fā)生發(fā)展相關(guān),包括膀胱癌和宮頸癌,其在腫瘤細(xì)胞中的過表達(dá)能促進腫瘤細(xì)胞的惡性增生及細(xì)胞轉(zhuǎn)移。
熱銷產(chǎn)品
TPX2 Antibody (CSB-PA892151LA01HU)
驗證數(shù)據(jù)

Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: TPX2 antibody at 3.5μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 86, 90 kDa
Observed band size: 86 kDa

IHC image of CSB-PA892151LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
TPX2 Antibodies
TPX2 for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
---|---|---|---|
CSB-PA024139GA01HU | TPX2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA560765 | TPX2 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA008292 | TPX2 Antibody | Human,Mouse | WB, IHC, ELISA |
CSB-PA784922 | TPX2 Antibody | Human,Mouse | ELISA,WB |
CSB-PA251071 | TPX2 Antibody | Human,Mouse | ELISA,WB,IHC |
CSB-PA892151LA01HU | TPX2 Antibody | Human | ELISA, WB, IHC |
CSB-PA892151LB01HU | TPX2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA892151LC01HU | TPX2 Antibody, FITC conjugated | Human | |
CSB-PA892151LD01HU | TPX2 Antibody, Biotin conjugated | Human | ELISA |
TPX2 Proteins
TPX2 Proteins for Homo sapiens (Human)
產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
---|---|---|
CSB-YP892151HU CSB-EP892151HU CSB-BP892151HU CSB-MP892151HU CSB-EP892151HU-B |
Recombinant Human Targeting protein for Xklp2 (TPX2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |