TREM2
TREM2，即髓樣細(xì)胞觸發(fā)受體2，它是一種主要在中樞神經(jīng)系統(tǒng)的小膠質(zhì)細(xì)胞中表達(dá)的跨膜受體蛋白。TREM2通過其胞外免疫球蛋白結(jié)構(gòu)域識別多種配體，包括病原體相關(guān)分子模式（PAMPs）和損傷相關(guān)分子模式（DAMPs）。其作用機(jī)制涉及與配體結(jié)合后激活下游信號通路，主要通過與DAP12結(jié)合，激活Syk激酶，進(jìn)而觸發(fā)包括PI3K、PLCγ和RAS/MEK/ERK等在內(nèi)的多種信號傳導(dǎo)途徑。這些信號通路影響小膠質(zhì)細(xì)胞的吞噬功能、細(xì)胞存活、代謝平衡和炎癥反應(yīng)。在生物學(xué)意義上，TREM2對維持中樞神經(jīng)系統(tǒng)穩(wěn)態(tài)、調(diào)節(jié)免疫反應(yīng)和參與神經(jīng)退行性疾病的發(fā)病機(jī)制具有重要作用。TREM2信號的異常激活與阿爾茨海默病等神經(jīng)退行性疾病的發(fā)生發(fā)展密切相關(guān)，是當(dāng)前神經(jīng)科學(xué)研究的熱點(diǎn)之一。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TREM2 Antibody (CSB-PA024405LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA024405LA01HU at dilution of 1:100
Immunofluorescence staining of HepG2 cells with CSB-PA024405LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Human Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit (CSB-EL024405HU)
驗(yàn)證數(shù)據(jù)
貨號：CSB-EL024405HU
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TREM2 Antibodies
TREM2 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA436852 | TREM2 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA024405LA01HU | TREM2 Antibody | Human | ELISA, IHC, IF |
| CSB-PA024405LB01HU | TREM2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA024405LC01HU | TREM2 Antibody, FITC conjugated | Human | |
| CSB-PA024405LD01HU | TREM2 Antibody, Biotin conjugated | Human | ELISA |
TREM2 for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA024405LA01MO | Trem2 Antibody | Mouse, Human | ELISA, WB |
| CSB-PA024405LD01MO | Trem2 Antibody, Biotin conjugated | Mouse | ELISA |
| CSB-PA024405LC01MO | Trem2 Antibody, FITC conjugated | Mouse | |
| CSB-PA024405LB01MO | Trem2 Antibody, HRP conjugated | Mouse | ELISA |
TREM2 Proteins
TREM2 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP024405MO CSB-BP024405MO CSB-EP024405MO-B |
Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP024405MO | Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial | E.coli |
| CSB-MP024405MO | Recombinant Mouse Triggering receptor expressed on myeloid cells 2 (Trem2), partial | Mammalian cell |
TREM2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | Yeast |
| CSB-EP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | E.coli |
| CSB-BP024405HU CSB-EP024405HU-B |
Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP024405HU | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | Mammalian cell |
| CSB-EP024405HUd1 | Recombinant Human Triggering receptor expressed on myeloid cells 2 (TREM2), partial | E.coli |
TREM2 ELISA Kit
TREM2 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL024405HU | Human Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit | serum, plasma, tissue homogenates | 0.078 ng/mL |
TREM2 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL024405MO | Mouse Triggering receptor expressed on myeloid cells 2(TREM2) ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
