TRIB3
TRIB3，即Tribbles同源蛋白3，它是一種在多種細(xì)胞類型中表達(dá)的假激酶。TRIB3能夠與多種蛋白質(zhì)相互作用，參與調(diào)節(jié)細(xì)胞的代謝、應(yīng)激反應(yīng)、炎癥以及細(xì)胞周期等過程。其作用機制包括通過與Akt等蛋白結(jié)合并影響其活性，進(jìn)而調(diào)控細(xì)胞的生存和代謝。在信號通路方面，TRIB3與PI3K-AKT-mTOR信號通路密切相關(guān)，它通過抑制Akt的磷酸化和活性，參與調(diào)節(jié)細(xì)胞的代謝和存活。在生物學(xué)意義上，TRIB3在糖尿病、癌癥、心血管疾病和神經(jīng)系統(tǒng)疾病的發(fā)生發(fā)展中可能發(fā)揮重要作用。研究表明，TRIB3的表達(dá)受多種應(yīng)激反應(yīng)的調(diào)控，如營養(yǎng)缺乏、缺氧、內(nèi)質(zhì)網(wǎng)應(yīng)激等，提示其在細(xì)胞應(yīng)激反應(yīng)中的"橋梁"作用。
熱銷產(chǎn)品
Recombinant Mouse Tribbles homolog 3 (Trib3) (CSB-EP818358MO)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TRIB3 Antibody (CSB-PA847220LA01HU)
驗證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA847220LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA847220LA01HU at dilution of 1:100
TRIB3 Antibodies
TRIB3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA024446GA01HU | TRIB3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA120599 | TRIB3 Antibody | Human | ELISA,IHC |
| CSB-PA592034 | TRIB3 Antibody | Human | ELISA,IHC |
| CSB-PA847220LA01HU | TRIB3 Antibody | Human | ELISA, IHC |
| CSB-PA847220LB01HU | TRIB3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA847220LC01HU | TRIB3 Antibody, FITC conjugated | Human | |
| CSB-PA847220LD01HU | TRIB3 Antibody, Biotin conjugated | Human | ELISA |
TRIB3 Proteins
TRIB3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP847220HU CSB-EP847220HU CSB-BP847220HU CSB-MP847220HU CSB-EP847220HU-B |
Recombinant Human Tribbles homolog 3 (TRIB3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
