TRPM8
TRPM8，即瞬時(shí)受體電位M8離子通道，它在多種哺乳動(dòng)物中表達(dá)，尤其是感覺神經(jīng)元中。TRPM8的作用機(jī)制是作為冷感受器，在溫度下降時(shí)被激活，允許鈣離子和鈉離子流入細(xì)胞，從而引發(fā)冷感覺信號(hào)的傳導(dǎo)。TRPM8對(duì)于動(dòng)物感知環(huán)境溫度變化、適應(yīng)低溫環(huán)境具有重要意義。此外，TRPM8還與某些疾病的發(fā)生發(fā)展有關(guān)，如前列腺癌、膀胱癌和乳腺癌。2021年諾貝爾生理學(xué)或醫(yī)學(xué)獎(jiǎng)授予了對(duì)溫度敏感的TRP通道的研究，這進(jìn)一步凸顯了TRPM8等通道在感知熱和冷以及適應(yīng)環(huán)境溫度中的重要性。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
CSB-MP768757HU1 is detected by Mouse anti-6*His monoclonal antibody.
TRPM8 Recombinant Monoclonal Antibody (CSB-RA186773A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA186773A0HU diluted at 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
TRPM8 Antibodies
TRPM8 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA768757LA01HU | TRPM8 Antibody | Human | ELISA, IHC, IF |
| CSB-PA768757ESR1HU | TRPM8 Antibody | Human | ELISA, IHC |
| CSB-PA969456 | TRPM8 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA072616 | TRPM8 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA186773A0HU | TRPM8 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
TRPM8 Proteins
TRPM8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP768757HU CSB-EP768757HU CSB-BP768757HU CSB-MP768757HU CSB-EP768757HU-B |
Recombinant Human Transient receptor potential cation channel subfamily M member 8 (TRPM8), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-MP768757HU1 | Recombinant Human Transient receptor potential cation channel subfamily M member 8 (TRPM8) , partial-VLPs | Mammalian cell |
