TRPV1
TRPV1，即瞬時(shí)受體電位香草醛亞家族1，別名VR1。它是一種配體門控的非選擇性陽離子通道，屬于瞬時(shí)受體電位通道家族。TRPV1主要分布在神經(jīng)系統(tǒng)，尤其在傷害性感受神經(jīng)元中，同時(shí)也在非神經(jīng)細(xì)胞如肥大細(xì)胞、膀胱上皮細(xì)胞、單核細(xì)胞等中廣泛分布。其作用機(jī)制涉及多種物理和化學(xué)刺激的響應(yīng)，如熱（>43℃）、質(zhì)子（pH<6.0）、機(jī)械力、滲透壓以及內(nèi)源性配體和外源性配體（如辣椒素）。
TRPV1介導(dǎo)瘙癢和疼痛反應(yīng)，參與糖尿病、呼吸疾病、心血管疾病、消化系統(tǒng)和皮膚系統(tǒng)的疾病進(jìn)程。TRPV1在腫瘤細(xì)胞中表達(dá)上調(diào)，可抑制腫瘤細(xì)胞的增殖、侵襲和遷移，誘導(dǎo)細(xì)胞周期阻滯和細(xì)胞凋亡，因此在抗癌研究中具有潛在的治療效果。目前，TRPV1已成為藥物研發(fā)的重要靶點(diǎn)，針對(duì)TRPV1的新藥物已開發(fā)用于改善糖尿病、心血管疾病和某些類型的癌癥。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
TRPV1 Antibody (CSB-PA822774LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA822774LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA822774LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-E14198h
規(guī)格：96T/48T
靈敏度：0.078 ng/mL
檢測(cè)范圍：0.312 ng/mL-20 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
TRPV1 Antibodies
TRPV1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA216653 | TRPV1 Antibody | Human | ELISA,IHC |
| CSB-PA037727 | TRPV1 Antibody | Human | ELISA,IHC |
| CSB-PA822774LA01HU | TRPV1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA822774LB01HU | TRPV1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA822774LD01HU | TRPV1 Antibody, Biotin conjugated | Human | ELISA |
TRPV1 Proteins
TRPV1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP025093RA CSB-EP025093RA CSB-BP025093RA CSB-MP025093RA CSB-EP025093RA-B |
Recombinant Rat Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TRPV1 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP734741DO CSB-EP734741DO CSB-BP734741DO CSB-MP734741DO CSB-EP734741DO-B |
Recombinant Dog Transient receptor potential cation channel subfamily V member 1 (TRPV1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TRPV1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP747826MO CSB-EP747826MO CSB-BP747826MO CSB-MP747826MO CSB-EP747826MO-B |
Recombinant Mouse Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TRPV1 Proteins for Cavia porcellus (Guinea pig)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP750924GU CSB-EP750924GU CSB-BP750924GU CSB-MP750924GU CSB-EP750924GU-B |
Recombinant Guinea pig Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TRPV1 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP750950RB CSB-EP750950RB CSB-BP750950RB CSB-MP750950RB CSB-EP750950RB-B |
Recombinant Rabbit Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TRPV1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP822774HU CSB-BP822774HU CSB-MP822774HU CSB-EP822774HU-B |
Recombinant Human Transient receptor potential cation channel subfamily V member 1 (TRPV1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP822774HU | Recombinant Human Transient receptor potential cation channel subfamily V member 1 (TRPV1), partial | E.coli |
| CSB-CF822774HU1 | Recombinant Human Transient receptor potential cation channel subfamily V member 1 (TRPV1), partial | in vitro E.coli expression system |
TRPV1 ELISA Kit
TRPV1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E14198h | Human transient receptor potential cation channel subfamily V member 1 (TrpV1)ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
