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TUSC3

Tumor suppressor candidate 3 is a protein in humans that is encoded by TUSC3 gene. Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.

TUSC3 Antibodies

TUSC3 for Homo sapiens (Human)

TUSC3 Proteins

TUSC3 Proteins for Mus musculus (Mouse)

TUSC3 Proteins for Homo sapiens (Human)

TUSC3 Proteins for Bos taurus (Bovine)