Th

酪氨酸羥化酶（Tyrosine Hydroxylase，TH）俗稱多巴胺合成酶，是大腦中調(diào)控神經(jīng)遞質生產(chǎn)的“總開關”。它能將酪氨酸轉化為左旋多巴，這是制造多巴胺、腎上腺素等關鍵神經(jīng)信號分子的第一步。TH活性不足會導致神經(jīng)系統(tǒng)“燃料短缺”，引發(fā)如Segawa綜合征等罕見遺傳病，患兒出生后逐漸出現(xiàn)四肢僵硬、運動失調(diào)，部分病例對左旋多巴藥物反應顯著。帕金森病患者腦內(nèi)TH水平通常下降50%以上，直接導致多巴胺耗竭，引發(fā)震顫和運動遲緩等典型癥狀。
當前治療以口服左旋多巴為主，但長期使用可能引發(fā)肢體不受控舞動等副作用。前沿研究嘗試通過基因療法在腦內(nèi)“定點補充”TH蛋白，例如英國Oxford Biomedica公司的OXB-102療法，已在靈長類動物中證實可持續(xù)6個月改善運動功能。小分子領域，默克公司開發(fā)的TH變構激活劑MK-8318，能繞過傳統(tǒng)代謝途徑直接增強酶活性，目前處于Ⅰ期臨床。

熱銷產(chǎn)品

TH Antibody (CSB-PA023470LA01HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate, Rat brain tissue, Rat liver tissue, Mouse liver tissue, Mouse brain tissue
All lanes: TH antibody at 4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 59, 56, 57, 46, 45 kDa
Observed band size: 59 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA023470LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA023470LA01HU at dilution of 1:100

Human tyrosine hydroxylase,TH ELISA Kit (CSB-E09661h)

驗證數(shù)據(jù)

貨號：CSB-E09661h

規(guī)格：96T/48T

靈敏度：0.078 ng/mL

檢測范圍：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Th Antibody

Th Protein

Th ELISA Kit

Th Antibodies

Th for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA154990	Phospho-TH (Ser40) Antibody	Human,Mouse,Rat	ELISA,IF
CSB-PA439504	Phospho-TH (Ser19) Antibody	Rat	ELISA,IF
CSB-PA695636	TH (Ab-31) Antibody	Mouse,Rat	ELISA,WB
CSB-PA000731	Phospho-TH (S19) Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA004284	TH Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA004285	TH Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA050254	Phospho-TH (S62) Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA050255	TH Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA011030	Phospho-TH (S71) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA195276	TH Antibody	Human	ELISA,IHC
CSB-PA903853	TH Antibody	Human	ELISA,IHC
CSB-PA023470LA01HU	TH Antibody	Human, Mouse, Rat	ELISA, WB, IHC
CSB-PA023470LB01HU	TH Antibody, HRP conjugated	Human	ELISA
CSB-PA023470LC01HU	TH Antibody, FITC conjugated	Human
CSB-PA023470LD01HU	TH Antibody, Biotin conjugated	Human	ELISA

Th for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA004286	TH Antibody	Rat	WB, IHC, ELISA
CSB-PA006345	Phospho-TH (S8) Antibody	Rat	WB, IHC, ELISA

Th Proteins

Th Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP023470HU CSB-EP023470HU CSB-BP023470HU CSB-MP023470HU CSB-EP023470HU-B	Recombinant Human Tyrosine 3-monooxygenase (TH)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli