VIM

VIM蛋白全稱波形蛋白，是Ⅲ型中間纖維的主要成分，構(gòu)成細(xì)胞骨架網(wǎng)絡(luò)維持細(xì)胞機械穩(wěn)定性。VIM在上皮細(xì)胞損傷修復(fù)時異常升高，促進細(xì)胞形態(tài)改變與遷移能力，其過度表達(dá)被視為上皮-間質(zhì)轉(zhuǎn)化的標(biāo)志物，與乳腺癌、胰腺癌的侵襲轉(zhuǎn)移密切相關(guān)。在纖維化疾病領(lǐng)域，肺、肝組織中的VIM沉積與器官硬化進程直接相關(guān)，阿爾茨海默病患者腦脊液內(nèi)也檢測到特異性片段積累。
針對VIM的治療策略多聚焦于抑制其病理聚合。小分子化合物Withaferin A從天然植物提取，可破壞VIM纖維結(jié)構(gòu)，在動物模型中有效減緩腫瘤轉(zhuǎn)移和肺纖維化進展，但存在肝腎毒性問題。單克隆抗體VN-18.2通過阻斷VIM與細(xì)胞膜整合素互作，已完成黑色素瘤治療的臨床前評估。近年來利用CRISPR技術(shù)敲低VIM表達(dá)改善心肌纖維化的研究引發(fā)關(guān)注，其載體遞送效率仍是轉(zhuǎn)化難點。

熱銷產(chǎn)品

Recombinant Human Vimentin (VIM) (CSB-EP025857HUc7)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

VIM Recombinant Monoclonal Antibody (CSB-RA025857MA1HU)

驗證數(shù)據(jù)

IHC image of CSB-RA025857MA1HU diluted at 1:40 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA025857MA1HU diluted at 1:40 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Rabbit IgG labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of NIH/3T3 cell with CSB-RA025857MA1HU at 1:40, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human vimentin,VIM ELISA Kit (CSB-E08982h)

驗證數(shù)據(jù)

貨號：CSB-E08982h

規(guī)格：96T/48T

靈敏度：7.8 pg/mL

檢測范圍：31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

VIM Antibody

VIM Protein

VIM ELISA Kit

VIM Antibodies

VIM for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA025857GA01HU	VIM Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA573495	VIM Antibody	Human,Mouse,Rat,Monkey	ELISA,WB,IF
CSB-PA084867	Phospho-VIM (Ser56) Antibody	Human	ELISA,WB
CSB-PA233606	VIM Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA000431	VIM Antibody	Human,Mouse,Rat	WB
CSB-PA004448	VIM Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA004449	VIM Antibody	Human	WB, IHC, IF, ELISA
CSB-PA004450	VIM Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA004451	VIM Antibody	Human	WB, ELISA
CSB-PA060073	Phospho-VIM (Y61) Antibody	Human	WB, ELISA
CSB-PA060074	Phospho-VIM (S83) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA060075	Phospho-VIM (S56) Antibody	Human	WB, IHC, ELISA
CSB-PA224594	VIM Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA200577	VIM Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA025857LA01HU	VIM Antibody	Human	ELISA, WB, IHC, IF
CSB-PA025857LB01HU	VIM Antibody, HRP conjugated	Human	ELISA
CSB-PA025857LC01HU	VIM Antibody, FITC conjugated	Human
CSB-PA025857LD01HU	VIM Antibody, Biotin conjugated	Human	ELISA
CSB-RA025857MA1HU	VIM Recombinant Monoclonal Antibody	Human	ELISA, IHC, IF

VIM for H, M, R

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-MA000319	VIM Monoclonal Antibody	Human,Mouse,Rat	ELISA,WB

VIM Proteins

VIM Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857MO CSB-BP025857MO CSB-EP025857MO-B	Recombinant Mouse Vimentin (Vim)	Yeast Baculovirus In Vivo Biotinylation in E.coli
CSB-EP025857MO	Recombinant Mouse Vimentin (Vim)	E.coli

VIM Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857RA CSB-EP025857RA CSB-BP025857RA CSB-MP025857RA CSB-EP025857RA-B	Recombinant Rat Vimentin (Vim)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857BO CSB-EP025857BO CSB-BP025857BO CSB-MP025857BO CSB-EP025857BO-B	Recombinant Bovine Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857HU	Recombinant Human Vimentin (VIM)	Yeast
CSB-EP025857HU	Recombinant Human Vimentin (VIM)	E.coli
CSB-BP025857HU CSB-MP025857HU CSB-EP025857HU-B	Recombinant Human Vimentin (VIM)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP025857HUc7	Recombinant Human Vimentin (VIM)	E.coli

VIM Proteins for Gallus gallus (Chicken)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857CH CSB-EP025857CH CSB-BP025857CH CSB-MP025857CH CSB-EP025857CH-B	Recombinant Chicken Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857PI CSB-EP025857PI CSB-BP025857PI CSB-MP025857PI CSB-EP025857PI-B	Recombinant Pig Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857DSU CSB-EP025857DSU CSB-BP025857DSU CSB-MP025857DSU CSB-EP025857DSU-B	Recombinant Chlorocebus aethiops Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857DXU CSB-EP025857DXU CSB-BP025857DXU CSB-MP025857DXU CSB-EP025857DXU-B	Recombinant Cricetulus griseus Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857OEI CSB-EP025857OEI CSB-BP025857OEI CSB-MP025857OEI CSB-EP025857OEI-B	Recombinant Oncorhynchus mykiss Vimentin (vim)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Mesocricetus auratus (Golden hamster)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857MRG CSB-EP025857MRG CSB-BP025857MRG CSB-MP025857MRG CSB-EP025857MRG-B	Recombinant Mesocricetus auratus Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857MOV CSB-EP025857MOV CSB-BP025857MOV CSB-MP025857MOV CSB-EP025857MOV-B	Recombinant Macaca fascicularis Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Pan troglodytes (Chimpanzee)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857EQV CSB-EP025857EQV CSB-BP025857EQV CSB-MP025857EQV CSB-EP025857EQV-B	Recombinant Pan troglodytes Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Cyprinus carpio (Common carp)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857EQE CSB-EP025857EQE CSB-BP025857EQE CSB-MP025857EQE CSB-EP025857EQE-B	Recombinant Cyprinus carpio Vimentin (vim)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

VIM Proteins for Ovis aries (Sheep)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP025857SH CSB-EP025857SH CSB-BP025857SH CSB-MP025857SH CSB-EP025857SH-B	Recombinant Sheep Vimentin (VIM)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli